Low Dose Versus High Dose Methylene Blue in Septic Patients
Septic Shock
About this trial
This is an interventional treatment trial for Septic Shock
Eligibility Criteria
Inclusion Criteria: Patients aged ≥ 18 years and ≤ 65 with septic shock as defined by Sepsis-3 criteria (confirmed infection, requiring vasopressor to maintain a mean arterial blood pressure (MAP) ≥ 65 mmHg, and serum lactate > 2 mmol/L after adequate fluid resuscitation), and requiring mechanical ventilation. Exclusion Criteria: myocardial infarction or cerebrovascular accident within the last 3 months. severe lung , liver or kidney disease (creatinine >3.5 mg/dL). pregnancy. glucose 6-phosphate-dehydrogenase deficiency. known allergy to MB or food dyes and the use of nitrates within the last 3 days. more than 24 hrs since initiation of norepinephrine. other causes of shock than sepsis . recent intake (4-weeks) of selective serotonin re-uptake inhibitors or MAOi. refusal of the patient guardian to participate.
Sites / Locations
- National Cancer InstituteRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Active Comparator
Normal saline
methylene blue low dose
methylene blue high dose
30 patients will receive placebo of 100ml 0.9% Nacl over 20 minutes followed by continuous infusion of Nacl for 72 hours.
30 patients will receive a bolus of MB 1mg/kg in 100ml 0.9% Nacl over 20 minutes followed by continuous infusion of 0.25mg/kg/hour for 72 hours.
30 patients will receive a bolus of MB 4mg/kg in 100ml 0.9% Nacl over 20 minutes followed by continuous infusion of 0.25mg/kg/hour for 72 hours.