Evaluation of Radiobiological Effects in Skin Toxicities for Breast Cancer Patients With Pencil Beam Scanning Proton Therapy
Breast Cancer, Breast Cancer Stage II, Breast Cancer Stage III
About this trial
This is an interventional supportive care trial for Breast Cancer
Eligibility Criteria
Inclusion Criteria: • The patient must consent to be in the study and must have signed an approved consent form conforming to federal and institutional guidelines. Patients must be 18 years old. The patient must have stage 0, I, II, or III breast cancer On histological examination, the tumor must be ductal carcinoma in-situ (DCIS) or invasive adenocarcinoma of the breast Surgical treatment of the breast must have been lumpectomy or mastectomy Patients must have an estrogen receptor (ER) analysis performed on the primary tumor Progesterone (PgR) analysis is desired but not mandatory Patients with a history of non-breast malignancies are eligible if they have been disease-free for 5 or more years No serious health conditions as determined by physician that would impact ability to complete treatment or impact skin in the area of treatment Exclusion Criteria: • Stage IV breast cancer Non-epithelial breast malignancies such as sarcoma or lymphoma Paget's disease of the nipple Prior breast or thoracic radiation therapy (RT) for any condition. Collagen vascular disease, specifically dermatomyositis with a Creatine phosphokinase (CPK) level above normal or with an active skin rash, systemic lupus erythematosis, or scleroderma. Pregnancy or lactation Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements.
Sites / Locations
- Thompson Proton CenterRecruiting