Time-restricted Eating Study (TRES): Impacts on Anthropometric, Cardiometabolic and Cardiovascular Health (TRES)
Myocardial Infarction
About this trial
This is an interventional prevention trial for Myocardial Infarction focused on measuring coronary heart disease, time-restricted eating, intermittent fasting
Eligibility Criteria
Inclusion Criteria: Adult, 18- 65 years old. Had history of acute coronary syndrome (ACS) Clinically stable Self-reported eating window of at least 12 h per day. Exclusion Criteria: Severe obesity (body mass index ≥40 kg m-2). Unstable weight in the past three months (gain or lose more than 4 kg of weight). Unstable cardiovascular, renal, cardiac, liver, lung, adrenal, or nervous system disease that may compromise study validity. Any medications or supplements known to change sleep, circadian rhythms, or metabolism. Pregnant or lactating women. Perform overnight shift work more than one day/week on average. Regularly fasted for more than 15 hours/day or having completed twelve 24-hr fasts within the past three months). Active use of tobacco or illicit drug or history of treatment for alcohol abuse. Type I diabetes or diabetic, treated with insulin. Use of anti-obesity drugs or other drugs affecting body weight. Currently enrolled in weight loss or management programme, including surgical intervention. Severe kidney failure (glomerular filtration rate (GFR) <30 mL/min). Eating disorder or current diagnosis of uncontrolled psychiatric illness, which may impair study involvement. Malignancy undergoing active treatment. Had gastrointestinal surgery or impaired nutrient absorption. Travelled more than two time zones away two months prior to enrolling in the trial or will travel more than two time zones away during the study period. Concurrent participation in other interventional studies
Sites / Locations
- Pusat Perkhidmatan Klinikal (CTC) UiTM
Arms of the Study
Arm 1
Arm 2
No Intervention
Experimental
Ad-libitum eating duration
Time-restricted eating (TRE) duration
24 patients will be randomly assigned to the control group. Participants will be asked to continue usual eating duration. Participants will receive the standard care and heart-healthy nutrition education.
24 patients will be randomly assigned to the intervention group. Participants in this arm will be asked to limit the number of hours they eat in a day to 10 hours in addition to receiving the standard of care health and heart-healthy nutrition education.