Efficacy of Intravenous Immunoglobulin in Patients With Hemorrhagic Fever With Renal Syndrome: a Prospective Study

Inclusion Criteria: The patients must meet all of the following criteria: Age ≥ 18 years, regardless of gender; Within 5 days of onset, hospitalized patients diagnosed with epidemic hemorrhagic fever (hemorrhagic fever with renal syndrome) must have at least one of the following laboratory test results: Positive for serum specific IgM(immunoglobulin M) antibodies; Or detect hantavirus RNA(ribonucleic acid) from patient specimens; Or the serum specific IgG(immunoglobulin G) antibody titer in the recovery phase is more than four times higher than that in the acute phase; Or hantavirus can be isolated from patient specimens. Meet any of the following criteria: 1. Severe illness: meet any of the following criteria: (i) Platelet count 20-50×10^9/L; (ii) White blood cell count 15-30×10^9/L. 2. Critical illness: meet any of the following criteria: (i) Platelet count<20×10^9/L; (ii) White blood cell count>30×10^9/L. Volunteer to join this study and be able to sign or have a written informed consent form signed by a legal representative. Exclusion Criteria: Exclude patients who meet any of the following criteria: Patients with primary chronic kidney disease; Patients with severe diabetes, hypertension, heart, lung, gastrointestinal tract, liver, autoimmune disease or nervous system disease; Have a history of malignant tumors (including solid malignant tumors and hematological malignancies etc.); Recent use of potentially nephrotoxic drugs; Pregnant or potentially pregnant patients; Patients with a history of hypersensitivity to IVIG (intravenous immunoglobulin) ; Selective IgA(immunoglobulin A) deficiency patients with IgA antibodies; Known or suspected immunodeficiency (human immunodeficiency virus infection, primary immunodeficiency), use of immunosuppressive drugs (glucocorticoids); Alcoholics, drug abuse, and psychiatric patients Other conditions which researchers deem not suitable for inclusion.