Clinical Trials Evaluating the Effect of Metformin Treatment on Function Endometrium in Women Diagnosed With Idiopathic Infertility (METIN)
Infertility, Female
About this trial
This is an interventional treatment trial for Infertility, Female
Eligibility Criteria
Inclusion Criteria: Age 18-45 No pregnancy for a minimum of 12 months prior to screening. Diagnosed with idiopathic infertility. No use of hormone therapy 30 days before screening. No use of any methods of contraception 30 days before screening and during the examination. BMI between 18.5 - 30 kg/m2. Exclusion Criteria: Positive pregnancy test result. Patients diagnosed with another factor of infertility. Patients with type I or II diabetes. Patients taking metformin or other hypoglycaemic drugs in the last 4 weeks before screening. Patients with hepatic impairment and abnormal liver function tests (alanine aminotransferase and/or aspartate aminotransferase (above 3x ULN). Patients with an eGFR less than 45 mL/min/1.73m2. Accompanying chronic diseases with poor prognosis. Patients with a history of lactic acidosis or other metabolic acidosis. Patients with a history of congestive heart failure III/IV NYHA degree. Patients with acute myocardial ischemia. Patients with sepsis or severe infection. Diseases which, in the opinion of the investigator, constitute an exclusion criterion and prevent the patient from participating in the study. Patients with predictable problems with cooperation with the research team.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Placebo Comparator
No Intervention
metformin
placebo
group without intervention
patients randomized to received metformin
patients randomized to received placebo