Effect of Esmolol on Oxygenation Index in Patients With Acute Respiratory Distress Syndrome
Acute Respiratory Distress Syndrome
About this trial
This is an interventional treatment trial for Acute Respiratory Distress Syndrome focused on measuring esmolol, ARDS, heart rate, oxygenation index
Eligibility Criteria
Inclusion Criteria: Meeting the 2012 Berlin diagnostic criteria for acute respiratory distress syndrome; Aged between 18-65 years (inclusive); 95 times/min ≤ heart rate ≤120 times/min; The patient needs to undergo endotracheal intubation mechanical ventilation after condition assessment; Obtain the informed consent of the patient or his legal representative. Exclusion Criteria: Bradycardia and second degree or more atrioventricular block; Long-term use of beta-blockers; Combined with emphysema, asthma and other β-blocker contraindicated diseases; Cardiac insufficiency (NYHA grade Ⅲ or Ⅳ); Pregnancy
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Esmolol group
Control group
Patients with ARDS who require mechanical ventilation after adequate disease assessment and whose heart rate continues to be ≥95 beats/min, but ≤120 beats/min within 24 hours after diagnosis, for at least 10 minutes without changing the dosage of catecholamine, were diagnosed as atrial fibrillation, atrial flutter or sinus tachycardia. The primary treatment is maintained while the esmolol load dose is administered and the maintenance dose is pumped continuously until the patient's heart rate is maintained between 80 and 94 beats per minute.
Patients with ARDS who need mechanical ventilation after adequate condition assessment and whose heart rate continues to be ≥95 beats /min but ≤120 beats /min after optimal hemodynamic treatment within 24 hours after diagnosis were randomly included in the control group. Routine mechanical ventilation, full sedation and analgesia, maintain RASS score 0-2 points; The target tidal volume is 6ml/kg, and the ventilator parameters should be adjusted in time according to the blood gas analysis. Hypotensive patients with sufficient blood volume should be pumped with pressor drugs. Timely sputum suction, airway management, eliminate fever, asthma, pain and other stimulation caused by the heart rate is too fast.