Using Vitamin D to Reduce Oral Mucosal Inflammation in Chemotherapy Patients With Oral Squamous Cell Carcinoma
Oral Squamous Cell Carcinoma, Oral Mucositis
About this trial
This is an interventional prevention trial for Oral Squamous Cell Carcinoma
Eligibility Criteria
Inclusion Criteria: Patients aged 20-70 years Patients with pathologically diagnosed oral squamous cell carcinoma who need TPF-based chemotherapy regimens, and whose expected survival time is greater than 6 months Patients whose serum 25-hydroxyvitamin D level was vitamin D deficiency (<30nmol/L) and adequate (30-50nmol/L) before chemotherapy Patients and their families agree to participate in this trial and sign an informed consent form No cognitive impairment Exclusion Criteria: People with oral ulcers or other oral mucosal diseases (such as: oral mucosal pemphigus, etc.) at the beginning of the study Patients who are allergic to alfacalcidol drops Patients with severe cardiac insufficiency, liver and kidney insufficiency, and systemic infectious diseases Pregnant women (judged by HCG test) and lactating patients Participating in other clinical trials during the study Those who do not understand or cooperate with clinical trials Patients with hypervitaminosis D, hypercalcemia, hyperphosphatemia and renal rickets
Sites / Locations
- Sun Yat-sen Memorial HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
intervention group
control group
Alfacalcidol Drops,1ug a day,40day
Placebo