Prophylaxis Against Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy
Postoperative Nausea and Vomiting, Laparoscopic Cholecystectomy
About this trial
This is an interventional treatment trial for Postoperative Nausea and Vomiting focused on measuring dexamethasone, dexmedetomidine, ondansetron
Eligibility Criteria
Inclusion Criteria: 70 Female patients aged between 18 and 65 years ASA I or II patients scheduled for elective laparoscopic cholecystectomy surgery will be included in this study. Exclusion Criteria: Females above 65 years old. patients under 18 years old. ASA > II. Obesity (BMI>40 kgm2). Known hypersensitivity to drugs used in the study protocol. Comorbidities that were known to increase the risk of PONV (e.g. vestibular disease). Liver or renal dysfunction (liver enzyme or creatinine 1.5 times higher than normal). Alcoholism or drug abuse. Use of antiemetics and psychotropic drugs or glucocorticoids within 24 h before surgery.
Sites / Locations
- Tanta University hospitalsRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Dexmedetomidine Group
Dexamethasone Group
will receive ondansetron 4mg + dexmedetomidine 0.5 ug/kg + normal saline to complete 10 ml. volume IV infusion over 10 minutes.
will receive Ondansetron 4mg + dexamethasone 8mg + normal saline to complete 10 ml. volume IV infusion over 10 minutes.