tDCS Associated With Symptom Provocation in the Management of Patients With Resistant Obsessive Compulsive Disorder (PPSTDCS-TOC)
Obsessive-Compulsive Disorder
About this trial
This is an interventional treatment trial for Obsessive-Compulsive Disorder
Eligibility Criteria
Inclusion Criteria: Patient suffering from OCD evolving for at least 2 years diagnosed according to DSM-V criteria; Patient with good insight, defined by a score less than or equal to 18 at the threshold of delusions on the BABS (Brown Assessment of Beliefs Scale) insight scale; Absence of a current depressive episode (MADRS score < 21) or suicidal risk (MADRS score item 10 < 3); Absence of epileptic pathology; Chronic obsessive-compulsive disorder defined by a total YBOCS score > 20, or a subscale score > 15; Drug-resistant obsessive-compulsive disorder despite treatment with: at least 2 antidepressants of the IRS type at an effective dose and for a sufficient duration and/or Behavioral and Cognitive therapy for at least 1 year; Therapeutic stability (antidepressants) for more than 12 weeks without significant improvement. This treatment, at a fixed dose, will be maintained during the study; Patient aged between 18 and 70 included Patient who has given his/her informed consent after having received written information on the planned procedure; Patient benefiting from social security or by benefiting through a third party. Exclusion Criteria: Woman of childbearing age without effective means of contraception (hormonal/mechanical: oral, injectable, transcutaneous, implantable, intrauterine device, or surgical: tubal ligation, hysterectomy, total oophorectomy) Pregnant or nursing woman; Patient hospitalized under duress (SPDT, SPDRE); Patient under guardianship or curatorship; Patient with another DSM-V Axis 1 diagnosis (Schizophrenic Disorder, Bipolar Disorder, Substance Abuse or Substance Dependence). Generalized anxiety disorder, social phobia, nicotine addiction and history of major depressive episodes are not exclusion criteria. Axis I comorbidity will be explored using MINI 5.0.0. ; Patient suffering from a current depressive episode; Patient at risk of suicide; Patient with skin lesions on the scalp; History of head trauma; Patient with an intracerebral metal object Patient with a pacemaker; Presence of epileptic pathology; Patient in an emergency situation or unable to give personal consent
Sites / Locations
- Centre Hospitalier Henri Laborit
Arms of the Study
Arm 1
Experimental
tDCS + symptoms provocation