Short Course Low Dose Oral Colchicine After ST Elevation Myocardial Infarction(STEMI)

Inclusion Criteria: Age between 18 years to 80 years old STEMI within 24 hours of admission to Pusat Perubatan UKM & undergoing revascularization therapy (percutaneous coronary intervention) during admission STEMI is diagnosed when there is: ST elevation of ≥1 mm in 2 contiguous leads or a new onset LBBB in the resting ECG in a patient with ischaemic type chest pains of > 30 minutes and accompanied by a rise and fall in cardiac biomarkers (CPG MALAYSIA STEMI 2019, 4th Edition) Exclusion Criteria: Pre-existing severe heart failure with left ventricular ejection fraction less than 35% Clinically unstable (Intubated or double inotropic support) Refuse or not suitable for cardiac revascularization therapy Anaemia induced Angina (Hb < 9 g/dL) Ongoing sepsis requiring antibiotic Ongoing diarrhea (Loose stool 3 times or more per day - stool consistency Bristol chart type 6 & 7) Active Covid-19 Infection (< 7 days for Category 1-3, < 10 days for category 4-5) Stroke within previous 3 months Coronary bypass surgery either within the previous 3 years or planned Active malignancy or treated malignancy within 7 years Active Inflammatory bowel disease on treatment Active Neuromuscular disease on treatment Chronic kidney disease (CKD stage 4 - eGFR < 30 mL/min/1.73 m2) Severe hepatic disease (ALT > 3X upper limit normal, Bilirubin > 2X upper limit normal) Active drug or alcohol abuse on therapy On long term or recent systemic glucocorticoid therapy within 3 months Pregnancy or breastfeeding Known sensitivity to colchicine or multivitamin tablet Pre-existing indication for colchicine therapy (Gout, Familial Mediterranean fever, etc) Patients on oral medications that may interact with colchicine (Clarithromycin, Ketoconazole, Voriconazole, Fluconazole, Itraconazole, Cyclosporine, Ritonavir)