The MARY-JANE Cannabis and Heart Rhythm Trial
Premature Atrial Contractions, Premature Ventricular Contractions
About this trial
This is an interventional other trial for Premature Atrial Contractions focused on measuring Cannabis, Marijuana, Weed, Arrhythmias, Cardiac Ectopy, PACs, PVCs, Heart Rhythm
Eligibility Criteria
Inclusion Criteria: Are age 21 or older Have a smartphone Are able to use the Eureka mobile application and Mosio text messaging software Have inhaled cannabis in the past month and on at least four different days in the same week in the past year Are willing to consume and abstain from inhaled cannabis for no more than two consecutive days as instructed over the 14-day trial period Exclusion Criteria: Currently pregnant or trying to get pregnant Have a medical reason to avoid cannabis Are unwilling to avoid all forms of cannabis consumption on days instructed to abstain from cannabis Are currently taking anti-arrhythmic medications Have a history of atrial fibrillation or heart failure Have congenital heart disease Have an implantable cardioverter-defibrillator or pacemaker Have had a previous cardiac ablation procedure
Sites / Locations
- UCSF Medical Center at Parnassus
- UCSF Medical Center at Mission Bay
Arms of the Study
Arm 1
Experimental
Case-crossover
Participants will be randomized in two-day blocks to consume then avoid cannabis ("Start: On Cannabis") or avoid then consume cannabis ("Start: Off Cannabis"). Using an case-crossover strategy delivered by the NIH-funded, UCSF-run Eureka platform utilizing a mobile smartphone-based application, or the Mosio text messaging software for clinical research, participants will receive instructions and answer questions to help researchers and physicians understand the relationship between inhaled cannabis and heart rhythm.