TB YOUTH - TB sYstemic Management Using One-month, Ultra-short TPT Regimen for scHool Contacts (TB-YOUTH)
Tuberculosis, Latent Tuberculosis
About this trial
This is an interventional prevention trial for Tuberculosis focused on measuring latent tuberculosis, TPT, active screening
Eligibility Criteria
Inclusion Criteria: Students of junior middle school, high school and university, age13 years old Close contact of school active tuberculosis case (e.g. in the same classroom, in the same dormitory, in the same floor) IGRA (Interferon-Gamma Release Assay) is positive and diagnosed as LTBI Himself/herself (together with his/her guardian for age under 18 years old) willing to participate in trial and sign informed consent. Exclusion Criteria: Current clinical or sputum culture confirmed active tuberculosis Had continuously taken rifamycin (rifampicin, rifapentine etc.) or isoniazid for more than 14 days in the past 2 years Have completed a full course of treatment for ATB or LTBI Allergic or intolerant to rifamycin (rifapentine or rifampicin) or isoniazid HIV (human immunodeficiency virus) antibody positive or AIDS (Acquired immunodeficiency syndrome) patients History of viral hepatitis (e.g. chronic hepatitis B, chronic hepatitis C) or liver cirrhosis Liver dysfunction (Total bilirubin > 5mg/dL (43 umol/L) or Alanine aminotransferase > 2ULN or Aspartate aminotransferase > 2ULN) or renal dysfunction Current receiving immunosuppressive therapy or biological agents Blood system diseases or Platelet count<50×10^9/L or White Blood Cell count<3.0×10^9/L Other conditions deemed unsuitable for TPT by physician.
Sites / Locations
- Central Hospital of Jingan DistrictRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
1H3P3 regimen of isoniazid and rifapentine 3 times a week for one month
3HR regimen of isoniazid and rifampicin once daily for three months
12-dose ultra-short TPT 1H3P3 regimen of isoniazid and rifapentine 3 times a week for one month
3HR regimen of isoniazid and rifampicin once daily for three months