A Study of Blood Pressure Control During Cancer Treatment

Inclusion Criteria: Age ≥ 18 years Female assigned at birth Biopsy proven breast cancer (stage I-IV) Planned treatment with cardiotoxic cancer therapy (e.g., anthracycline chemotherapy, with or without HER2-targeted therapy) SBP ≥130 mm Hg Willing and able to comply with the requirements of the protocol. Participant must have and be willing to use their bluetooth enabled wifi or cellular mobile device (For participants in the CPET cohort): Able to complete an acceptable baseline CPET, in the absence of high-risk ECG findings or other inappropriate response to exercise as determined by the PI, as defined by any of the following criteria: Achieving a plateau oxygen consumption, concurrent with an increase in power output; A respiratory exchange ratio ≥ 1.10; Attainment of maximal predicted heart rate, as defined by a peak heart rate within 10bpm of the age predicted maximal heart rate (220 - Age[years]); Volitional exhaustion, as measured by a rating of perceived exertion (RPE) ≥ 18 on the BORG scale. Exclusion Criteria: eGFR < 30 ml/min/1.73m2 (based upon Cockcroft-Gault, etc.) Individuals with arm circumference too large to allow accurate BP measurement with available BP devices Inability to accurately measure blood pressure in at least one arm (e.g., bilateral upper extremity lymphedema) Cardiac comorbidity, including any of the following: Acute coronary syndrome within 3 months prior to randomization. Symptomatic heart failure (NYHA class III/IV) within past 6 months History of stroke Cardiac transplantation Other medical disorder or condition that in the opinion of the investigator would impair the subject's ability to participate or adhere to study interventions (For participants in the CPET cohort): Subjects must not have any of the following absolute contraindications to cardiopulmonary exercise testing: Acute myocardial infarction (within 30 days of any planned study procedures), Unstable angina Uncontrolled arrhythmias causing symptoms or hemodynamic compromise, Symptomatic severe aortic stenosis Recurrent syncope Active endocarditis Acute myocarditis or pericarditis Acute pulmonary embolus or pulmonary infarction (within 3 months of any planned study procedures) Thrombosis of lower extremities (within 3 months of any planned study procedures) Suspected dissecting aneurysm Uncontrolled asthma Pulmonary edema Room air desaturation at rest ≤85% Respiratory failure Acute noncardiopulmonary disorder that may affect exercise performance or be aggravated by exercise (i.e., infection, renal failure, thyrotoxicosis) Mental impairment leading to inability to cooperate.