Gluten-free Diet in PSC and IBD
Primary Sclerosing Cholangitis, Ulcerative Colitis, Biliary Tract Diseases
About this trial
This is an interventional treatment trial for Primary Sclerosing Cholangitis focused on measuring Primary sclerosing cholangitis, Cholangitis, Gluten-free diet, Ulcerative Colitis, Microbiome
Eligibility Criteria
Inclusion Criteria (for PSC group): Established diagnosis of PSC (based on radiologic features, typical finding on MRCP or ERCP) Age 18 - 65 years ALP 1,5x higher than ULN Signed informed consent Exclusion Criteria (for PSC group): Patients on gluten-free diet Patients with coeliac disease or wheat allergy Liver transplant recipients PSC/AIH overlap syndrome Other causes of liver disease Radiologic or clinical signs of decompensated liver cirrhosis Advanced liver cirrhosis (MELD score ˃ 15) Recurrent acute cholangitis or cholangiogenic sepsis in past 3 months Use of antibiotics in past 3 months History of malignancy Pregnant women Not signed informed consent Inclusion criteria (for UC group): Ulcerative colitis diagnosed based on clinical, endoscopic and histological findings Extension of affected colon > 15cm Mayo score 0-4 Signed informed consent Exclusion criteria (for UC group): CMV, Clostridium difficile enterocolitis in past 3 months Use of antibiotics in past 3 months Patients with coeliac disease or wheat allergy Patients on gluten-free diet Pregnant women Not signed informed consent Biologic therapy Methotrexate Prednison > 10 mg Not signed informed consent
Sites / Locations
- Institute of clinical and experimental medicineRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Primary sclerosing cholangitis
Ulcerative Colitis