Mechanical Insufflation-Exsufflation (Cough Assist) in Critically Ill Adults (ACACIA)
Critically Ill
About this trial
This is an interventional treatment trial for Critically Ill focused on measuring Mechanical insufflation-exsufflation, Cough Assist
Eligibility Criteria
Inclusion Criteria: admission to one of the participating ICUs; receiving invasive mechanical ventilation via an endotracheal tube; and expected to need invasive ventilation for more than 48 hours from consideration for inclusion. Exclusion Criteria: use of MI-E before hospital admission, i.e., at home; known presence of bullous emphysema; known bronchopleural fistula; known pneumothorax or pneumomediastinum; known rib fractures; known barotrauma; known unstable spinal fractures; unsecured subarachnoidal haemorrhage; uncontrollable intracranial pressures; and any infection, or colonization with pathogens that requires strict aerogenic isolation. With an exception for patients in cohort isolation due to COVID-19.
Sites / Locations
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)Recruiting
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Mechanical Insufflation-Exsufflation
Standard airway care
Invasively ventilated patients will receive MI-E until successful extubation or for a maximum of 7 days. MI-E will be given in the morning and afternoon each calendar day. Patients will be pre-oxygenated with FiO2 100% prior to disconnection from the ventilator; additional 15 litres oxygen can be added; A pre-set program is used: three times three cycles with a 2-second insufflation and an immediate 2-second exsufflation. The cycles of the MI-E session will be performed with a positive and negative pressure of 40 cmH2O. The program is set up with the possibility of auto-triggering by the patient.
Patients in the control group will receive usual airway care which includes endotracheal suctioning and manual hyperinflation used when indicated based on clinical signs as part of regular airway care. Care protocols for endotracheal suctioning and manual hyperinflation are predefined. As with the intervention arm, there will be no use of saline instillation during suctioning. Manual hyperinflation technique is described in the care protocol of the intensive care unit and ICU nurses are trained to perform this technique.