Blood Flow Regulation and Neuromuscular Function Post-Stroke
Stroke
About this trial
This is an interventional treatment trial for Stroke
Eligibility Criteria
Inclusion Criteria: Be between 18-85 years of age Able to give informed consent ≥6 months post diagnosis of unilateral cortical or sub-cortical stroke English speaking Exclusion Criteria: History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (e.g. wounds in the leg) Chronic pain syndrome Low back or hip pain that interferes with lower extremity motor testing History of head trauma Comorbid neurological disorder Peripheral vascular disease Myocardial infarction in the previous year Inability to follow 2 step commands Condition where fatiguing contractions or resisted leg contractions are contraindicated Resting SBP ≥160 mmHg or DBP ≥ 110 mmHg Pregnancy or breastfeeding.
Sites / Locations
- Medical College of Wisconsin
- Marquette University
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
Ischemic Conditioning
Ischemic Conditioning Sham
Ischemic conditioning is a well-defined, non-invasive procedure which consists of inflating a blood pressure cuff around a limb (in our study, the paretic leg), inflating the cuff to 225 mmHg to occlude blood flow to the limb for 5 minutes, releasing the cuff for 5 minutes, and repeating 5 times. In our study, participants will receive six sessions of ischemic conditioning over the course of two weeks.
There will also be an IC Sham group which is identical to the IC intervention, except the cuff will only be inflated to 10 mmHg, which is not a high enough pressure to occlude arterial blood flow.