Short Contact Protocols to Reduce Pain During 10% ALA Gel Red-light Photodynamic Therapy of Actinic Keratoses
Actinic Keratosis
About this trial
This is an interventional treatment trial for Actinic Keratosis focused on measuring Actinic Keratoses, Actinic Keratosis, Photodynamic Therapy
Eligibility Criteria
Inclusion Criteria: Minimum of 10 actinic keratoses lesions on the face. Female subjects must not become pregnant during the study Subjects must be able to understand and willing to sign a written informed consent document. Exclusion Criteria: Pregnant or nursing. Using any topical treatment on their AKs; must stop at least one month prior. Currently undergoing treatment for other cancers with medical or radiation therapy. Patients with a known hypersensitivity to 5-aminolevulinic acid or any component of the study material. Patients with history of a photosensitivity disease, such as porphyria cutanea tarda.
Sites / Locations
- Cleveland Clinic, Dermatology and Plastic Surgery Institute, Case Comprehensive Cancer Center
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
Regimen A
Regimen B
Regimen C
Apply topical aminolevulinic acid gel and incubate for 10 minutes prior to red light source
Apply topical aminolevulinic acid gel and incubate for 20 minutes prior to red light source
Apply topical aminolevulinic acid gel and incubate for 60 minutes prior to red light source