Cerebrovascular Health and Resilience in Midlife (CHARM)

Inclusion Criteria: Able to attend 2 study visits at the University of Pittsburgh campus in Oakland (Pennsylvania) Able to read and speak English Exclusion Criteria: Uncontrolled hypertension (systolic blood pressure >160 or diastolic blood pressure >100 mmHg) Current use of anticonvulsant, anti-Parkinson, neuroleptic, or antipsychotic medications Current use of glucocorticoids (e.g., oral prednisone) or ephedrine Current chronic conditions of the lungs, liver and kidney, as well as cancer (chemotherapy and radiation) treatment in the past 12 months (allowances are made for non-melanoma skin cancer treatment, controlled asthma, and allergy inhalers) Self-reported major neurological disorders or brain injuries (e.g., multiple sclerosis, cerebral palsy, major head injury) Self-reported psychotic illnesses (mania, bipolar disorder, schizophrenia) Current pregnancy or childbirth within the past 6 months Suspected mild cognitive impairment or dementia Self reported sleep apnea Self-reported history of myocardial infarction, stroke, or revascularization procedures, as well as treatment for cardiac arrhythmias Self-reported lack of comfort to undergo MRI testing Presence of implants or objects that are unsafe for MRI (e.g., tattooed eyeliner), as well as any other contraindications that would prevent MRI testing Self-reported lack of comfort to undergo the laboratory math task