Accelerated, Theta-burst Stimulation for the Treatment of Post-concussion Syndrome

Inclusion Criteria: Documented evidence of head trauma sufficiently severe to result in loss of consciousness, post-traumatic amnesia and/or acute altered mental status. At least three symptoms including headache, dizziness, fatigue, irritability, insomnia, memory difficulties, concentration difficulties, mood dysregulation. Onset of symptoms within 4 weeks following the head trauma. Age 18-60, inclusive. Persistence of PCS symptoms for at least 3 months but less than 12 months Able to provide informed consent and comply with the study protocol Patients will not be excluded solely on the basis of communication (i.e., non-English speaking) unless they have exclusion criteria that is the cause of the communication difficulties. Exclusion Criteria: Evidence of major structural neuroimaging abnormalities (e.g., intracranial hemorrhage, skull fracture or a large intracranial lesion) History of prior rTMS therapy, Contraindications to MRI (e.g., pacemaker, metallic implants etc.). Ferromagnetic, non-removable metallic implants from above the clavicle with the exception of dental work. Active personal injury litigation History of seizure disorder, not including febrile seizures in childhood Substance dependence within the last 6 months Pregnant Currently taking more than lorazepam 2 mg daily (or benzodiazepine equivalent) or any dose of an anticonvulsant (due to the potential to reduce rTMS efficacy) Currently taking an antiepileptic medication Mild and major comorbid medical conditions (as determined by investigators - e.g., neurological diseases, uncontrolled hypertension or diabetes, malignancy) A major comorbid psychiatric disorder (as determined by investigators - e.g., schizophrenia or bipolar disorder) and/or psychosis at the time of study enrollment