Double-blind Placebo Controlled Study to Evaluate the Effect of NAD+ Boosting With Nicotinamide Riboside on Immunometabolism and Immunity in Systemic Lupus Erythematosus

INCLUSION CRITERIA: In order to be eligible to participate in this study, an individual must meet all of the following criteria: SLE subjects: Female subjects 18 years or older who meets > 3 of 11 modified Am. Coll. of Rheumatology (ACR) (1997) Revised Criteria for SLE and mild/moderate disease activity defined as an SLE Disease Activity Index 2000(SLEDAI 2K) more than or equal to 2 and less than or equal to 14 at screening; If on glucocorticoids, the dose must be less than or equal to 20 mg daily and stable for at least 4 weeks prior to screening; If on hydroxychloroquine or other antimalarials such as chloroquine or quinacrine, dose must have been stable for the 12 weeks prior to screening. The max. allowed doses - hydroxychloroquine 400 mg/day, chloroquine phosphate 500 mg/day and quinacrine 100 mg/day; Subjects of childbearing potential must agree to practice effective birth control for the duration of the study; Stated willingness to comply with all study procedures and availability for the duration of the study; Agreement to adhere to Lifestyle Considerations throughout study duration; Ability of subject to understand and the willingness to sign a written informed consent document. Control subjects: Female subjects 18 years or older No history of autoimmune or inflammatory disease; EXCLUSION CRITERIA: SLE Subjects: Active renal or central nervous system disease or major renal or hepatic dysfunction; Treatment with rituximab, belimumab or any other biologic agent within the 6 months prior to screening Current treatment with specific immunosuppressive drugs (methotrexate, azathioprine, mycophenolate mofetil, cyclosporine, tacrolimus); Treatment with cyclophosphamide or IVIG within the 6 months prior to screening and or increase in glucocorticoid dose within 4 weeks of screening; Dietary vitamin B3 or tryptophan supplementation within 6 weeks of screening. Pregnancy or lactation (nursing) Treatment with another investigational drug or other intervention within 6 months of screening Control Subjects: Inability to sign consent Dietary vitamin B3 or tryptophan supplementation within 6 weeks Pregnancy or nursing Pregnant women are excluded from participation on this study. Self-reported pregnancy status may be accepted from female control participants of child-bearing potential for a blood draw which is considered a minimal risk procedure.