Inhalational Anesthesia vs. Intravenous Anesthesia (GASvsIV)
Neurocognitive Disorders, Anesthesia, Post-operative Delirium
About this trial
This is an interventional prevention trial for Neurocognitive Disorders
Eligibility Criteria
Inclusion criteria: Men and women ≥ 75 years Sufficient vision and hearing to complete all tests Proficient in spoken and written English Scheduled for elective, inpatient, noncardiac surgery, expected to last at least 120 minutes requiring general anesthesia Informant available with frequent (at least 1 hour/day or 1 day/week) contact with the subject to verify CDR rating. Exclusion criteria: Urgent or emergent surgery Diagnosed dementia (or MoCA<19) History of stroke, Parkinson's disease, major psychiatric disease (Schizophrenia), or severe traumatic brain injury Ongoing alcohol or substance abuse (per DSM V criteria) Allergy to propofol or sevoflurane Personal or family history of malignant hyperthermia Planned postoperative intubation Brain surgery Surgery requiring TIVA or GAS (i.e. cases involving neuromonitoring) Surgical procedure requiring general, regional, or neuraxial anesthetic occurring within 3 months (before or after) surgical date Any patient or perioperative factor considered a contraindication to randomization to either experimental group by the surgeon or anesthesiologist.
Sites / Locations
- Oregon Health & Science UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Inhalational Anesthesia
Intravenous Anesthesia
Inhalational maintenance of anesthesia group using sevoflurane
Intravenous maintenance of anesthesia group using propofol