Thyroxine Therapy for Recurrent Pregnancy Loss in Hypothyroid Women
Recurrent Early Pregnancy Loss, Thyroid Diseases
About this trial
This is an interventional treatment trial for Recurrent Early Pregnancy Loss focused on measuring Miscarriage, Hypothyroidism, Thyroid Stimulating Hormone, Thyroxin
Eligibility Criteria
Inclusion Criteria: Women aged 18 to 40 years old. Diagnosis of recurrent pregnancy loss, defined as two or more pregnancy losses in the first trimester. Confirmed thyroid function test results with TSH levels either between 2.5 and 4 or higher than 4. Willing and able to give informed consent for participation in the study. Exclusion Criteria: Women who are currently taking thyroid medication before the study starts. Presence of other causes of recurrent pregnancy loss such as antiphospholipid syndrome, uterine abnormalities, genetic/chromosomal disorders, etc. Presence of other severe chronic diseases like heart disease, kidney disease, uncontrolled diabetes, etc. Known allergy or intolerance to thyroxine.
Sites / Locations
- AL-Elwiyah Maternity Teaching Hospital
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Thyroid Stimulating Hormone 2.5-4 mU/L
Thyroid Stimulating Hormone more than 4 mU/L
This arm consists of participants who have experienced recurrent pregnancy loss in the first trimester and have TSH levels ranging between 2.5 mU/L and 4 mU/L. These participants will receive levothyroxine treatment of 1.6 micrograms per kg per day
This arm consists of participants who have experienced recurrent pregnancy loss in the first trimester and have TSH levels more than 4 mU/L. These participants will receive levothyroxine treatment of 1.6 micrograms per kg per day