Efficacy of Ivermectin-albendazole vs Albendazole Alone in School-aged Children Infected With Trichuris Trichiura (FACEITeffic)
Trichuriasis
About this trial
This is an interventional treatment trial for Trichuriasis focused on measuring Soil-transmitted helminths, Trichuris trichiura
Eligibility Criteria
Inclusion Criteria: Written informed consent for participation signed from caregivers; and written assent by participants. Agree to comply with study procedures, including provision of two stool samples at the beginning (baseline) and at follow-up assessment 14-21 days after treatment. Willing to be examined by a study nurse/physician prior to treatment. At least two slides of the quadruple Kato-Katz thick smears positive for T. trichiura. Exclusion Criteria: Presence or signs of major systemic illnesses, e.g. body temperature ≥ 38°C, clinical malaria (fever + positive RDT) upon initial clinical assessment. Recent use of anthelmintic drug (within past 4 weeks). Attending other experimental research studies. Known allergy to study medications (i.e. benzimidazole or ivermectin).
Sites / Locations
- Vector Borne & Neglected Tropical Disease Control Division, Ministry of Health
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
IVM (200 µg/kg) + ALB (400 mg)
ALB (400mg)
A single tablet of albendazole (400mg) plus 200 µg/kg of ivermectin, provided as single oral dose.
A single tablet of albendazole (400mg), provided as single oral dose.