Effect of Immersive Virtual Reality-based Cognitive Remediation in Patients With Mood - or Psychosis Spectrum Disorders
Bipolar Disorder, Depression, Psychotic Disorders
About this trial
This is an interventional treatment trial for Bipolar Disorder focused on measuring Cognition, Cognitive Impairment, Cognitive Remediation, Depression, Bipolar Disorder, Schizophrenia, Schizotypal Disorder, Psychotic Disorders, Virtual Reality
Eligibility Criteria
Inclusion Criteria: Fluent Danish skills Meet the International Classification of Diseases 10th edition (ICD-10) diagnosis of unipolar disorder, bipolar disorder (types I and II) or a psychosis spectrum disorder (i.e. F20-F29) confirmed using the Schedules for Clinical Assessment in Neuropsychiatry (SCAN) interview Patients must have objective and subjective cognitive impairment at the time of inclusion. Objective cognitive impairment is defined a total score on the Screen for Cognitive Impairment in Psychiatry - Danish version (SCIP-D) ≥ 0.5 standard deviations (SD) below the expected total score based on age, education, and gender or as a score ≥ 0.5 SD below the expected score on a minimum of two out of the five subtests (verbal learning test - immediate, working memory test, verbal fluency test, verbal learning, test - delayed, and processing speed test). Subjective cognitive impairment is defined as a score ≥ 14 on the Cognitive Complaints in Bipolar Disorder Rating Scale (COBRA). Exclusion Criteria: Current drug or substance abuse A daily use of benzodiazepines >22.5 mg oxazepam or >7.5 mg diazepam (cutoffs for doses with limited cognitive side effects) Comorbid neurological disorder Previous serious head trauma Dyslexia Pregnancy Claustrophobia (fMRI scan) Having a pacemaker or other metal implants inside the body (fMRI scan) Having had electroconvulsive therapy in the 3 months prior to inclusion
Sites / Locations
- Neurocognition and Emotion in Affective Disorders (NEAD) Centre, Copenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Frederiksberg hospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
Virtual reality Based Cognitive Remediation
Virtual reality control treatment
The cognitive remediation program has a duration of four weeks and involves two weekly 1,5-hour virtual reality-based cognitive training sessions with a therapist accompanied by additional between-session virtual reality training at home and homework assignments consisting of cognitively challenging daily life tasks.
The control treatment program also has a duration of four weeks and involves one weekly 2-hour session with a therapist.