α-Mangostin Hydrogel Film With Chitosan Alginate Base for Recurrent Aphthous Stomatitis (RAS) (AM-RAS)
Recurrent Aphthous Stomatitis
About this trial
This is an interventional treatment trial for Recurrent Aphthous Stomatitis
Eligibility Criteria
Inclusion Criteria: Age 18-40 years Healthy subjects without mouth diseases Not using drugs for RAS therapy Not involved with other clinical trials Willing to participate Exclusion Criteria: Have a mouth disease Have other serious illnesses, including arrhythmia, uncontrolled hypertension, diabetes, hepatitis, and kidney failure pregnant or lactating women, and women who wish to become pregnant during the study period poor oral hygiene that requires treatment chronic diseases requiring treatment with antibiotics, hormones, nonsteroidal anti-inflammatory drugs, immunosuppressants, immune enhancers, cytotoxic drugs, or cell cycle agents that affect the oral mucosa mental illness or limited mental capacities
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
α-Mangostin Hydrogel Film With Chitosan Alginate Base
Placebo
Subjects will receive α-Mangostin Hydrogel Film With Chitosan Alginate Base in the form of a patch. Subjects will apply the patch once a day after breakfast or at night before sleep, subjects will be told to avoid drinking or eating for 1 hour after using the hydrogel film because these activities can remove the hydrogel film. Ulcer size and VAS score will recorded on the first day (baseline), the 3rd day, the 5th day, and the 7th day
Subjects will receive Hydrogel Film With Chitosan Alginate Base without an active compound in the form of a patch. Subjects will apply the patch once a day after breakfast or at night before sleep and will be told to avoid drinking or eating for 1 hour after using the hydrogel film because these activities can remove the hydrogel film. Ulcer size and VAS score will recorded on the first day (baseline), the 3rd day, the 5th day, and the 7th day