Study of RMC-9805 in Participants With KRASG12D-Mutant Solid Tumors
Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma (PDAC)
About this trial
This is an interventional treatment trial for Non-small Cell Lung Cancer (NSCLC) focused on measuring KRAS G12D (ON), NSCLC, CRC, PDAC, Non-small Cell Lung Cancer, Lung Cancer, Colorectal Cancer, Colon Cancer, Pancreatic Cancer, Metastatic Cancer, Pancreatic Ductal Adenocarcinoma, Pancreatic Neoplasms, Colorectal Neoplasms, Gastrointestinal Neoplasms, KRAS, Colonic Neoplasms
Eligibility Criteria
Inclusion Criteria: Pathologically documented, locally advanced or metastatic solid tumor malignancy with KRASG12D-mutations identified through deoxyribonucleic acid (DNA) sequencing or polymerase chain reaction (PCR) test Received and progressed or been intolerant to prior standard therapy (including targeted therapy) appropriate for tumor type and stage ECOG performance status 0 or 1 Adequate organ function Exclusion Criteria: Primary central nervous system (CNS) tumors Known or suspected leptomeningeal or active brain metastases or spinal cord compression Known or suspected impairment of gastrointestinal function that may prohibit ability to swallow or absorb an oral medication Participant was previously treated with an investigational KRASG12D inhibitor or had prior therapy with any direct RAS-targeted therapy (eg, degraders and inhibitors) Other inclusion/exclusion criteria may apply.
Sites / Locations
- STARTRecruiting
- NEXT Oncology VirginiaRecruiting
Arms of the Study
Arm 1
Experimental
RMC-9805
Dose exploration and dose expansion