Open Label Trial to Evaluate the Adhesion of TK-254RX in Healthy Volunteers.

Inclusion Criteria: age: 18 to 64 years good state of health non-smoker or ex-smoker for at least 3 months written informed consent, after having been informed about benefits and potential risks of the clinical trial, as well as details of the insurance taken out to cover the subjects participating in the clinical trial Exclusion Criteria: The following must not apply: any injury of body which may induce the restriction of body movement excessively hairy skin at application site current skin disorder or shaving hair at application site history of excessive sweating/hyperhidrosis inclusive of application site participation in a clinical study within 30 days before inclusion in the study or concomitantly drug or alcohol abuse in the opinion of the investigator pregnant and lactating women women of child-bearing potential who do not agree to apply highly effective contraceptive methods known hypersensitivity to active ingredient, its racemate or one of the excipients of the TK-254RX existing cardiac and/or haematological diseases or pathological findings, which might interfere with the safety or tolerability of the active ingredient existing hepatic and/or renal diseases or pathological findings, which might interfere with the safety or tolerability of the active ingredient known liver or kidney insufficiency existing gastrointestinal diseases or pathological findings, which might interfere with the safety or tolerability of the active ingredient history of relevant CNS and/or psychiatric disorders and/or currently treated CNS and/or psychiatric disorders systolic blood pressure < 90 or > 139 mmHg diastolic blood pressure < 60 or > 89 mmHg pulse rate < 50 bpm or > 90 bpm subjects who use any impermissible medication