Brain and Stress Study (BASS)
Stress, Psychological, Motivation
About this trial
This is an interventional basic science trial for Stress, Psychological
Eligibility Criteria
Inclusion Criteria: 25-50 years old Unemployed (working less than 20 hours per week) Have been unemployed for at least 6 months Seeking employment Having trouble finding a job (i.e., actively seeking and applying for jobs but not successful in landing a job) Reports greater than 5 points on Job Stress Items Regular access to a mobile phone Exclusion Criteria: Self-reported physical illnesses: diabetes, cardiovascular diseases, high blood pressure, inflammatory bowel diseases, rheumatoid arthritis, asthma, autoimmune disease, Crohn's disease, ulcerative colitis, lupus neurological conditions (e.g., Traumatic Brain Injury, stroke) pregnant (as measured by urine pregnancy screen) or breastfeeding current use of psychotropic medications Current regular recreational drug or alcohol use (i.e., 4 or more times per week) chronic diseases that significantly impact inflammatory markers (e.g., cancer) known allergies or hypersensitivities to tetracycline antibiotics, aspirin or other NSAIDs current antibiotic use regular use of steroidal or non-steroidal anti-inflammatory medications (i.e., 2 or more times a week)
Sites / Locations
- Howell HallRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Placebo followed by Minocycline
Minocycline followed by Placebo
In this arm, participants will take a 5-day course of placebo-control pills and then a 5-day course of 200 mg of minocycline. Sessions will be separated by a minimum washout period of 14 days.
In this arm, participants will take a 5-day course of 200 mg of minocycline and then a 5-day course of placebo-control pills. Sessions will be separated by a minimum washout period of 14 days.