Evaluation of the Effect of Liposomal L-Arg and Vit C Integration on Mitochondrial Function in Patients With Heart Failure (Mito-HF)
Heart Failure
About this trial
This is an interventional treatment trial for Heart Failure focused on measuring Mitochondrial, PBMC, L-Arg, Vit C
Eligibility Criteria
Inclusion Criteria: Age ≥18 years Diagnosis of heart failure with preserved EF 45%. Exclusion Criteria: Age <18 years Left ventricular ejection fraction <45% Valvular heart disease Previous myocardial infarction or coronary heart disease Hypertension Diabetes mellitus Intolerance to L-arginine and liposomal vitamin C Pregnancy Lactation.
Sites / Locations
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore PoliclinicoRecruiting
Arms of the Study
Arm 1
Arm 2
Placebo Comparator
No Intervention
Treatment group
Control group
Once the diagnosis of heart failure is established, patients will be randomized into a double-blind treatment to receive with a 1:1 ratio an oral supplement of 1.66 g L-arginine and 500 mg of liposomal vitamin C once a day (Bioarginine. C , Pharmaceutical Damor) for 3 months (treatment group)
Once the diagnosis of heart failure is established, patients will be randomized into a double-blind treatment to receive with a 1:1 ratio an oral supplement of Placebo for 3 months (control group)