Sevoflurane's Effect on Neurocognition Study (SENS)
Anesthesia, Pain, Amnesia
About this trial
This is an interventional basic science trial for Anesthesia focused on measuring functional MRI, sevoflurane, electric nerve stimulation, sedation, functional connectivity
Eligibility Criteria
Inclusion Criteria: Adults, age 18-59, who are native English speakers with at least a high school education have normal hearing and memory be of normal body-weight be generally healthy (free from significant chronic disease) have none of the specific exclusion criteria have a valid email address and valid phone number throughout the study anticipate ability to participate in all visits required for the phase of the study in which they are enrolled Exclusion Criteria: being pregnant or attempting to conceive having a body mass index (BMI) > 35 having significant memory impairment or hearing loss having sleep apnea having chronic pain or frequently taking pain medication (including tramadol) having any severe or poorly-controlled medical problem (hypertension, diabetes) having neurologic or psychiatric disease, including anxiety, and depression having significant cardiac valvular disease or cardiomyopathy having a history of abnormal heartbeats (cardiac conduction abnormality or arrhythmia) having a history of seizures or convulsions having a history of liver disease having a history of asthma or other significant pulmonary disease having a history of malignant hyperthermia, muscular dystrophy, central core disease, or hyperkalemia being claustrophobic have metal implants or non-removable metal piercings having a history of adverse reaction to anesthetics daily alcohol or heavy alcohol use; history of alcohol abuse current daily smoker regular or recent marijuana use (including prescribed/medical marijuana) illicit drug use regularly taking: antiepileptics, antidepressants, anti-psychotics, antihistamines, anti-anxiety medication, stimulants, or sleep-aids current use of selective serotonin reuptake inhibitors (SSRIs), noradrenaline reuptake inhibitors (SNRIs), or monoamine oxidase inhibitors (MAOIs) and some other specific drugs phenytoin, carbamazepine, and rifampin history of QT prolongation hypersensitivity or allergic reaction to ondansetron (Zofran)
Sites / Locations
- University of PittsburghRecruiting
Arms of the Study
Arm 1
Experimental
Sevoflurane+Pain
Single-arm study. All subjects receive sevoflurane and painful electric nerve stimulation, as described in the interventions.