A Study of Orforglipron (LY3502970) Compared With Semaglutide in Participants With Type 2 Diabetes Inadequately Controlled With Metformin (ACHIEVE-3)
Type 2 Diabetes
About this trial
This is an interventional treatment trial for Type 2 Diabetes
Eligibility Criteria
Inclusion Criteria: Have Type 2 Diabetes Have HbA1c ≥7.0% (53 mmol/mol) to ≤10.5% (91 mmol/mol), as determined by the central laboratory at screening. Have been on stable diabetes treatment with metformin ≥1500 milligram (mg)/day during the 90 days prior to screening and maintained through randomization. Are of stable body weight (±5%) for at least 90 days prior to screening and agree to not initiate an intensive diet or exercise program during the study with the intent of reducing body weight, other than the lifestyle and/or dietary measures for diabetes treatment Exclusion Criteria: Have Type 1 Diabetes Are currently receiving or planning to receive treatment for diabetic retinopathy and/or macular edema, for example, laser photocoagulation or intravitreal injections of anti-vascular endothelial growth factor inhibitors. Have a history of ketoacidosis or hyperosmolar state or coma within the last 6 months prior to screening, or between screening and randomization. Have a New York Heart Association functional classification IV congestive heart failure. Have an estimated glomerular filtration rate (eGFR) <45 milliliter/minute (mL/min)/1.73 square meter (m²) or lower than the country-specific threshold for discontinuing metformin therapy per local label as determined by the central laboratory at screening. Have a serum calcitonin level of ≥35 nanogram/Liter (ng/L), as determined by the central laboratory at screening. Have a history of an active or untreated malignancy or are in remission from a clinically significant malignancy for less than 5 years.
Sites / Locations
- Absolute Clinical ResearchRecruiting
- San Fernando Valley Health InstituteRecruiting
- Neighborhood Healthcare Institute of HealthRecruiting
- Velocity Clinical Research, GardenaRecruiting
- Biopharma InformaticRecruiting
- National Research Institute - WilshireRecruiting
- Infinity Clinical Research - Norco
- Valley Clinical Trials, Inc.Recruiting
- Norcal Endocrinology & Internal MedicineRecruiting
- Encompass Clinical ResearchRecruiting
- New West Physicians Clinical Research
- Connecticut Clinical Research - CromwellRecruiting
- Clinical Research of West Florida, Inc. (Clearwater)Recruiting
- South Florida Clinical Research InstituteRecruiting
- Miami Dade Medical Research Institute, LLCRecruiting
- West Orange EndocrinologyRecruiting
- Latin Clinical Trial Center FloridaRecruiting
- Clinical Research of West FloridaRecruiting
- Metabolic Research Institute, Inc.Recruiting
- Balanced Life Health Care Solutions/SKYCRNG
- Clinical Research AtlantaRecruiting
- North Georgia Clinical ResearchRecruiting
- Northwest Clinical TrialsRecruiting
- Family First Medical CenterRecruiting
- American Health Network of IN, LLC
- Velocity Clinical Research, ValparaisoRecruiting
- Cotton O'Neil Clinical Research CenterRecruiting
- Tekton Research - WichitaRecruiting
- DelRicht ResearchRecruiting
- Joslin Diabetes Center
- Revival Research Institute - DearbornRecruiting
- SKY Integrative Medical Center/SKYCRNGRecruiting
- Kansas City Research InstituteRecruiting
- Glacier View Research Institute - Endocrinology
- Premier ResearchRecruiting
- Albany Medical College, Division of Community EndocrinologyRecruiting
- Ellipsis Research GroupRecruiting
- Great Lakes Medical Research, LLCRecruiting
- PharmQuestRecruiting
- Lucas Research, IncRecruiting
- Accellacare - PiedmontRecruiting
- Wake Forest University Baptist Medical Center (WFUBMC)Recruiting
- Aventiv Research IncRecruiting
- Tekton Research, IncRecruiting
- Alliance for Multispecialty Research, LLCRecruiting
- The Corvallis Clinic, P.C.Recruiting
- Heritage Valley Medical Group, Inc.Recruiting
- Office 18Recruiting
- The Research Center of The UpstateRecruiting
- New Phase Research and DevelopmentRecruiting
- Clinical Neuroscience Solutions, Inc. dba CNS HealthcareRecruiting
- Velocity Clinical Research, AustinRecruiting
- Dallas Diabetes Research CenterRecruiting
- Diabetes and Thyroid Center of Ft. WorthRecruiting
- Juno ResearchRecruiting
- Endocrine Ips, PllcRecruiting
- Clear Brook Medical AssociatesRecruiting
- Southern Endocrinology AssociatesRecruiting
- Texas Valley Clinical Research
- Synexus Clinical Research US, Inc.Recruiting
- Eastside Research AssociatesRecruiting
- Rainier Clinical Research CenterRecruiting
- Centro de Investigaciones Metabólicas (CINME)
- CIMeL Clinical Research
- Centro de Investigaciones Médicas Mar del Plata
- Policlinica Red OMIP
- Centro Médico ViamonteRecruiting
- Instituto Centenario
- Consultorio de Investigación Clínica EMO SRL
- Centro de Salud e Investigaciones Médicas
- Instituto de Especialidades de la Salud Rosario
- Instituto de Investigaciones Clinicas Zarate
- Instituto Médico Catamarca IMEC
- Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica
- Fundacion Estudios Clinicos
- Instituto de Investigaciones Clínicas Córdoba
- Instituto Médico DAMIC
- Sanatorio Norte
- Beijing Pinggu District Hospital
- Chongqing General Hospital
- Huizhou Municipal Central Hospital
- The First Affiliated Hospital of Henan University of Science &Technology
- Nanyang First People's Hospital
- The Second Affiliated Hospital of Zhengzhou University
- Nanjing First Hospital
- The Second Affiliated Hospital of Nanjing Medical University
- Dalian Municipal Central Hospital Affiliated of Dalian Medical University
- Jinan Central Hospital
- Pudong New Area People's Hospital Shanghai
- Shanghai Sixth People's Hospital
- West China Hospital of Sichuan University
- Chengdu Fifth People's Hospital
- First Affiliated Hospital of Kunming Medical University
- Zhejiang Hospital
- Huzhou Central Hospital
- The First Affiliated Hospital of Wenzhou Medical University
- Mikannohana Clinic, Diabetes, Endocrinology and MetabolismRecruiting
- Manda Memorial HospitalRecruiting
- Nakamoto Internal Medicine ClinicRecruiting
- Nakakinen clinicRecruiting
- Ohishi Internal Medicine ClinicRecruiting
- Takai Internal Medicine ClinicRecruiting
- Shiraiwa Medical ClinicRecruiting
- Medical Corporation Sato Medical clinic
- Gifu University Hospital
- CAIMED México
- Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares
- Instituto Jalisciense de Investigacion en Diabetes y Obesidad
- Centro de Investigacion Medica Integral
- Consultorio Médico
- CICEJ Centro de Investigación Clínica Endocrinológica de Jalisco S.C
- Private Practice - Dr. Arechavaleta Granell Maria del Rosario
- Virgen Cardiovascular Research SC
- Centro de Investigacion Medica de Occidente, S.C.
- Cardiolink Clin Trials
- Unidad biomedica avanzada monterrey
- Clínica García Flores SC
- Eukarya PharmaSite
- Centro de investigación y control metabólico
- Centro Para El Desarrollo de La Medicina Y de Asistencia Medica Especializada S.C.
- Lahoja. Asociacion Para La Investigacion Y La Farmacovigilancia
- Private Practice - Dr. Paola Mansilla-LetelierRecruiting
- Research and Cardiovascular Corp.Recruiting
- Latin Clinical Trial CenterRecruiting
- Endocrinologist Metabolic Clinic & Research InstituteRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Active Comparator
Active Comparator
Orforglipron Dose 1
Orforglipron Dose 2
Semaglutide Dose 1
Semaglutide Dose 2
Participants will receive orforglipron orally.
Participants will receive orforglipron orally.
Participants will receive semaglutide orally.
Participants will receive semaglutide orally.