Oral Care With 3% Hydrogen Peroxide (Oroxid®) in ICU - Effects on the Lower Airway Microbial Colonisation (HyperMICROBE)
VAP - Ventilator Associated Pneumonia
About this trial
This is an interventional prevention trial for VAP - Ventilator Associated Pneumonia focused on measuring pneumonia, hydrogen peroxide, chlorhexidine, respiratory tract microbiome
Eligibility Criteria
Inclusion Criteria: Age ≥18 years In-patient of ICU and expected to stay > 5 days Mechanical ventilation or imminent need of it; predicted length of mechanical ventilation (MV) ≥ 72h Clinical Pulmonary Infection score (CPIS) less than 6 at the baseline No history and symptoms of aspiration at the baseline Exclusion Criteria: ATB therapy on admission Suspected pulmonary infection on admission and in the first 48h of mechanical ventilation Pregnancy Oral ulcers or injuries Patient with a history of hydrogen peroxide allergy
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Hydrogen Peroxide
Chlorhexidine
Intervention group: daily oral care will be provided according to the local standard, with 3% hydrogen peroxide, oral assessment and teeth brushing will be completed twice daily (morning and evening).
Control group: daily oral care will be provided according to the local standard, with 0,2% chlorhexidine, oral assessment and teeth brushing will be completed twice daily (morning and evening).