NIV for Hypercapnic Respiratory Failure: AVAPS vs S/T BIPAP
Hypercapnic Respiratory Failure
About this trial
This is an interventional treatment trial for Hypercapnic Respiratory Failure focused on measuring AVAPS, BIPAP, Hypercapnic respiratory failure, Noninvasive ventilation
Eligibility Criteria
Inclusion Criteria: Provision of signed and dated informed consent form directly by the patient; consent can also be obtained via a legal patient representative/health care proxy/surrogate Stated willingness to comply with all study procedures and availability for the duration of the study Male or female, aged 18 or older Diagnosed with hypercapnic respiratory failure on admission (ABG) Admitted to Lenox Hill Hospital medical intensive care unit or telemetry unit Requiring noninvasive ventilation as determined by the treating physician for the treatment of hypercarbic respiratory failure Exclusion Criteria: Patients who require ventilation at predetermined tidal volumes Patients who require rapid and frequent IPAP adjustments to maintain a consistent tidal volume Age less than 18 years of age Currently intubated Chronic tracheostomy Pregnancy Hypotension Epistaxis (nosebleed) Untreated pertussis Acute sinusitis or Otitis media Patients at risk of aspirating gastric contents Patients with lack of spontaneous respiratory drive Patients with the inability to maintain a patent airway or adequately clear secretions Prisoners or other institutionalized individuals
Sites / Locations
- Lenox Hill Hospital
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Average Volume-Assured Pressure Support (AVAPS)
Bilevel Positive Airway Pressure Spontaneous Timed (BIPAP S/T)
Average Volume-Assured Pressure Support (AVAPS) setting on the noninvasive ventilator. The exact AVAPS setting will be titrated by the clinical team involved directly in the patient's care based on patient comfort and clinical response.
Bilevel Positive Airway Pressure Spontaneous Timed (BIPAP S/T) setting on the noninvasive ventilator. The exact BIPAP S/T setting will be titrated by the clinical team involved directly in the patient's care based on patient comfort and clinical response.