Early Cessation of Sedation and TTM in Patients With a Favourable EEG After Cardiac Arrest (SELECT)
Hypoxia-Ischemia, Brain, Heart Arrest
About this trial
This is an interventional treatment trial for Hypoxia-Ischemia, Brain focused on measuring EEG, targeted temperature management (TTM)
Eligibility Criteria
Inclusion Criteria: Patients after cardiac arrest admitted to the ICU for treatment with sedation, TTM and mechanical ventilation. Age 18 years or older. Continuous EEG measurement started within 12 hours after cardiac arrest. Favourable EEG pattern within 12 hours after arrest, defined as a continuous background pattern (NVN, 2019; Ruijter et al., 2019). Possibility to stop sedative treatment within three hours after identification of a favourable EEG pattern. Written informed consent (deferred). Exclusion Criteria: A known history of another medical condition with limited life expectancy (<6 months). Any progressive brain illness, such as a brain tumour or neurodegenerative disease. Pre-admission Glasgow Outcome Scale Extended score of 4 or lower. Reason other than neurological condition to continue sedation and/or ventilation. Follow-up impossible due to logistic reasons.
Sites / Locations
- Rijnstate hospital
- Medisch Spectrum Twente
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Early cessation of sedation and TTM
Standard Care
Early cessation of sedation and targeted temperature management (TTM), with subsequent weaning from mechanical ventilation if appropriate (intervention group).
Standard care, including sedation and targeted temperature management (TTM) for at least 24-48 hours (control group).