Comparative Study Between Preoperative and Postoperative Rectal Misoprostol
Blood Loss, Surgical, Blood Loss, Postoperative
About this trial
This is an interventional prevention trial for Blood Loss, Surgical focused on measuring blood loss, Cesarean Section, Oxytocin, Rectal Misoprostol
Eligibility Criteria
Inclusion Criteria: Gestational age ( 37 to 41 weeks). Singleton healthy fetus. Scheduled for elective lower segment caesarean delivery under spinal anaesthesia. Body mass index of (25-30 Kg/m2). Normal coagulation profile. Normal amniotic fluid volume assessed by amniotic fluid index. Exclusion Criteria: Maternal comorbidity: Hypertension; diabetes; heart, kidney, or liver disorders. Contraindication to use of misoprostol like known allergy to misoprostol or asthmatic patients. Women who had undergone any previous uterine surgery such as myomectomy because it is considered upper uterine segment operation with more destruction in myometrium but caesarean section is a lower segment uterine operation with minimal destruction in myometrium. Women at higher risk of intraoperative blood loss or PPH, such as those with hemoglobin levels less than 9 g/dl, history of PPH, or uterine fibroids. Antepartum hemorrhage ( placenta previa and placental abruption). Women who will undergo caesarean section because of failure of induction of labor.
Sites / Locations
- Faculty of medicine, Cairo UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Pre-operative and post-operative rectal misoprostol
Post-operative rectal misoprostol
64 participants who will receive combined pre-operative and post-operative rectal misoprostol (400μg rectal misoprostol during urinary catheter insertion just after spinal anesthesia plus 200μg after abdominal closure).
64 participants who will receive rectal misoprostol post-operative only (600μg of rectal misoprostol after closure of the Cesarean Wound)).