Novel Amblyopia Treatment With Virtual Reality Games

Inclusion Criteria: Patients ages 5 to 17 years of age Moderate to severe unilateral amblyopia (logMAR best corrected visual acuity 0.3 to 1.3) associated with anisometropia and/or strabismus of ≤5pd Age normal VA in the nonamblyopic eye Spectacle correction (if required) worn for at least 16 weeks, or until stability of VA is demonstrated (<0.1 logMAR change by the same testing method measured on 2 exams at least 8 weeks apart) Interocular difference of ≥ 3 lines No amblyopia treatment in the past 2 weeks An interpupillary distance of 52-72 mm (inclusive) Exclusion Criteria: Myopia greater than -6.00 diopters (D) spherical equivalent in either eye. Previous intraocular or refractive surgery. Previous dichoptic treatment > 2 weeks in duration Ocular co-morbidity that may reduce visual acuity determined by an ocular examination performed within the past 7 months (Note: nystagmus per se does not exclude the participant if the above visual acuity criteria are met). Diplopia more than once per week over the last week prior to enrollment by parental report. Down syndrome or cerebral palsy. Light-induced seizures Known simulator sickness Severe developmental delay that would interfere with treatment or evaluation (in the opinion of the investigator). Participants with mild speech delay or reading and/or learning disabilities are not excluded.