Efficacy of Rehabilitation Using Action Observation and Muscle Stimulation in Post-stroke Patients. (OTHELLO)
Stroke, Stroke Sequelae
About this trial
This is an interventional treatment trial for Stroke
Eligibility Criteria
Inclusion Criteria: Age 50<years<=80; Upper arm motor impairment after unilateral ischemic first ever stroke as verified by MRI or CT; Two weeks up to 6 months after stroke; Grading of upper arm motor impairment>2 at Medical Research Council scale (MRC). Exclusion Criteria: Neurological/orthopedic issues that would interfere with upper limb exercises; Presence of any medical condition that represents a contraindication to Magnetic Resonance Imaging (MRI) examination or to Transcranial Magnetic Stimulation (TMS); Presence of dermatologic issues that will interfere with neuromuscular stimulator; Presence of electronic subcutaneous implants; Presence of peripheral neuropathy; Epilepsy; Pregnancy; Presence of severe cognitive impairment, including language comprehension detected during the neurological evaluation.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Active Comparator
Placebo Comparator
Action Observation Therapy (AOT) associated with Neuromuscular Electrical Stimulation (NMES)
Action Observation Therapy (AOT)
Observation of motor-neutral stimuli (MNO)
The group will receive 5 consecutive days a week, for 4 weeks, 45 minutes-long sessions of action observation therapy (AOT) associated with a synchronous neuromuscular stimulation of motor synergies (NMES). After AOT-NMES, subjects will be asked to repeat the observed movement.
The group will receive 5 consecutive days a week, for 4 weeks, 45 minutes-long sessions of action observation therapy (AOT). The neuromuscular electrical stimulator will be placed on the subjects' arm without synchronous stimulation. After AOT, subjects will be asked to repeat the observed movement.
The group will receive 5 consecutive days a week, for 4 weeks, 45 minutes-long sessions of motor-neutral observation (MNO). The neuromuscular electrical stimulator will be placed on the subjects' arm without synchronous stimulation. After MNO, subjects will be asked to execute movements.