A Study of a Plant-Based Diet and Dietary Supplements in People With Smoldering Multiple Myeloma (SMM)

Inclusion Criteria: Confirmed prior diagnosis of smoldering myeloma (anytime prior). However, confirmation of SMM diagnosis must be documented in their last local oncologist clinic note within 3 months prior to study enrollment. Age ≥18 years Willingness to comply with all study-related procedures Physically able to complete requirements for the study or has someone to assist with the requirements (such as meal preparation, stool shipment and survey completion) Interested in learning to cook plant based recipes Access to smart mobile phone or device with camera and ability to download Keenoa app Be residing within the United States for the study duration. English speaking or a family member or caregiver who speaks English and is able to assist with the surveys and phone based Keenoa app. Exclusion Criteria: Taking any supplements other than vitamin D, iron, vitamin B12, potassium, magnesium, calcium or those needed for a medical indication must be reviewed by PI. If patient is on a supplement (including curcumin, probiotic, omega3) they must stop these for 2 weeks prior to enrollment on study. Patients that already follow a whole foods plant based diet (ovo-lactovegetarian or processed junk food vegan diets are not excluded). This will be per research dietitian evaluation and discretion after nutrition screening. Legume allergy Severe allergies such as anaphylactic shock to peanuts and/or tree nuts, such as cashews Concurrent participation in weight loss/dietary trials or defined programs (that require specified diets/supplements on the program) Mental impairment leading to inability to cooperate Enrollment onto any other therapeutic investigational study Concurrent pregnancy Patients on full dose anticoagulation ≥ Grade 2 electrolyte (sodium and potassium) abnormalities as defined by CTCAEv5.0 (need to be resolved before enrolling on study) If in the opinion of the investigator there maybe any concerns regarding the ability of the patient to complete the study safely Current self reported heavy alcohol use (defined as >2 drinks per day or >14 drinks per week) Current self-reported illicit drug use (except inhaled marijuana, vaping or cigarette smoking. Oral marijuana/THC excluded or must stop >2 weeks prior.) Has a condition requiring antibiotics within 14 days of study intervention administration. Plan for travel during the study that would preclude adherence to prescribed diets History of active inflammatory bowel disease or major gastrointestinal surgery (not including appendectomy or cholecystectomy) within 3 months of enrollment or any history of total colectomy, or bariatric surgery (bariatric surgery which does not disrupt the gastrointestinal lumen, i.e. restrictive procedures such as banding, are permitted)