TAP Block Versus Conventional Systemic Analgesia (TAPLAP)
Analgesia
About this trial
This is an interventional treatment trial for Analgesia
Eligibility Criteria
Inclusion Criteria: All patients scheduled for elective laparoscopic cholecystectomy at the department of surgery, Mahmoud El Matri Hospital, Ariana Exclusion Criteria: Severe renal insufficiency (GFR < 30 ml/min) Severe hepatic insufficiency (TT ≤ 50%) Severe COPD (FEV1 > 30%) Metastatic malignancy Hematologic disease or a congenital clotting disorder Preoperative opioid use Age under 18 years Pregnancy or breast-feeding Hyper-reactivity toward ropivacaine Estimated risk for conversion to open surgery > 50%
Sites / Locations
- Department of surgery, Mahmoud El Matri hospital, Ariana, Tunisia
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
TAP block
Conventional analgesia
Bilateral TAP block is administered intraoperatively at laparoscopy, directly after insufflation and insertion of the first trocar and camera. The ultrasound probe is placed longitudinally on the midaxillary line near umbilicus, and the transversus abdominis and internal oblique muscles are scanned and observed. The needle (22-gauge 90 mm disposable spinal needle) is inserted in plane. After placing the needle-tip into the fascia between transversus abdominis and internal oblique muscles, Ropivacaine 0.25% (Naropin) is injected bilaterally at the dose of 0.5 mg/kg. It is all done by one Anesthetist which is expert in that area and is not in charge of collecting the data. No additional regional anesthesia, including epidural or spinal anesthesia, is given. The patients are mobilized in the recovery room 2 h after surgery.
No additional regional anesthesia, including epidural or spinal anesthesia, is given. For postoperative analgesia, all patients receive paracetamol intravenously at the dose of 1 g three times up to 24 hours, starting immediately after surgery. Complementary opioids are given on request when pain numerical rating scale (pain NRS) : NRS > 3 at rest or for pain NRS > 5 on exercise. Oxycodone is given intravenously at the dose of 0.05 mg/kg only in the recovery room up to two hours after the surgery. It is administrated intramuscularly at the dose of 0.1 mg/kg up to 24 hours after surgery. Then, it is given orally at the dose of 0.2 mg/kg from 24 to 48 hours after surgery.