Optimization of OnabotulinumtoxinA (BTX-A) Injection for the Treatment of Neurogenic Lower Urinary Tract Dysfunction (BOND)
Neurogenic Bladder, Lower Urinary Tract Symptoms, Overactive Bladder
About this trial
This is an interventional treatment trial for Neurogenic Bladder focused on measuring neurogenic bladder, Lower urinary tract symptoms, Neurogenic detrusor overactivity, Onabotulinum toxinA
Eligibility Criteria
Inclusion Criteria: Adult men and women (>18 years of age) with a diagnosis of neurological conditions such as MS, PD, CVA, myelomeningocele, SCI, or traumatic brain injury longer than 6 months prior to treatment. Diagnosis of neurogenic bladder indicated for treatment with BTX-A for OAB symptoms. Participants must be able to provide informed consent, as well as understand and be willing to undergo. follow-up procedures and completion of all questionnaires provided during the study. Exclusion Criteria: Symptomatic UTI at the time of procedure, defined as positive nitrites or high-volume leukocyte esterase on urine dip in addition to at least one of the following symptoms: dysuria, gross hematuria, suprapubic pain, frequency/urgency above baseline. Diagnosis of bladder pain syndrome or other chronic pain syndrome including fibromyalgia, chronic pelvic pain, pelvic floor dysfunction, levator myalgia. Untreated bladder malignancy. Women who are currently pregnant or breast feeding. Contraindications to intradetrusor BTX-A injections.
Sites / Locations
- Houston Methodist HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Standard Injection Sites
Reduced Injection Sites
Standard number of injections
Reduced number of injections