Biomarkers of Reaction To HIIT Exercise (BReaTHE)
Stroke, Stroke Rehabilitation, Lower Extremity Weakness, Spastic
About this trial
This is an interventional treatment trial for Stroke focused on measuring Predictors of Stroke Rehabilitation, Biomarkers of Stroke Rehabilitation, Exercise Intervention, Neuroimaging
Eligibility Criteria
Inclusion Criteria: chronic left or right subcortical stroke as defined by 6 months or more after a cardiovascular accident lower extremity motor impairment due to stroke that causes a walking speed of less than 0.6 m/s during a 10m walk age 18-80 years old Veteran status. Exclusion Criteria: MRI contraindications, including implanted cardiac pacemakers and severe claustrophobia any neurodegenerative condition other than stroke that may lead to lower extremity impairment a visual or auditory impairment that may hinder study procedures any medical condition that would preclude participation in a physical exercise intervention program.
Sites / Locations
Arms of the Study
Arm 1
Experimental
Chronic Stroke with lower limb disability
The investigators will enroll 55 Veterans with chronic subcortical stroke in the 12-week HIIT intervention, with the expectation that 48 participants (85%) will complete the entire program. In our experience, 65% of participants will respond to the HIIT intervention, resulting in an estimated 31 responders and 17 resistors. Each chronic subcortical stroke participant will be asked to participate in the HIIT study protocol. Classification of resistor or responder: A responder to the 12-week HIIT intervention will be defined as a participant who increases their walking speed to greater than 0.6 m/s. A resistor to the intervention will be defined as a participant who does not increase their walking speed to greater than 0.6 m/s.