Protocol for Comparing the Efficacy of Three Reconstruction Methods of the Digestive Tract After Proximal Gastrectomy
Proximal Gastric Adenocarcinoma, Gastrectomy, Anastomosis
About this trial
This is an interventional treatment trial for Proximal Gastric Adenocarcinoma
Eligibility Criteria
Inclusion Criteria: Age between 20-75 years old, male or female; Pathological diagnosis of preoperative endoscopic biopsy: the tumor is located in the upper 1/3 of the stomach (including the esophagogastric junction), and the clinical staging of gastric cancer: Ia and Ib (T1N0M0, T1N1M0, and T2N0M0) (14) according to the eighth edition of the AJCC (15); No distant metastasis observed on preoperative chest radiograph, abdominal ultrasound or upper abdominal CT; ASA grade 1-3; Patients without contraindications to surgery; Patients and their families voluntarily signing the informed consent form and participating in the study; Exclusion Criteria: Patients diagnosed with primary tumors or distant metastasis; Patients whose tumor is located in the greater curvature side of the stomach; Patients with coagulation dysfunction which could not be corrected; Patients who were diagnosed with viral hepatitis and cirrhosis; Patients who were diagnosed with diabetes mellitus, uncontrolled or controlled with insulin; Patients with organ failure such as heart, lung, liver, brain, kidney failure; Patients with ascites or cachexia preoperatively in poor general conditions; Patients diagnosed with immunodeficiency, immunosuppression or autoimmune diseases (such as allogeneic bone marrow transplant, immunosuppressive drugs, SLE, etc.). Patients refusing to sign the informed consent of the study;
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Active Comparator
Active Comparator
Kamikawa reconstruction
STJI reconstruction
SOFY reconstruction
Patients will be administered Kamikawa reconstruction after proximal gastrectomy.
Patients will be administered Single-Tract Jejunal Interposition(STJI) reconstruction after proximal gastrectomy.
Patients will be administered SOFY reconstruction after proximal gastrectomy.