Sodium-glucose Transport 2 Inhibitors (SGLT2i) in HFrEF Patients
Heart Failure, Reduced Ejection Fraction Heart Failure
About this trial
This is an interventional treatment trial for Heart Failure
Eligibility Criteria
Inclusion criteria: Patients with HFrEF, on optimal medical therapy according to European Society of Cardiology guidelines, an age of at least 18 years, an ejection fraction of 40% or less, with New York Heart Association (NYHA) class II - IV symptoms will be eligible for the study. Exclusion criteria: Recent treatment with or unacceptable side effects associated with an SGLT2i Type-I diabetes mellitus, Symptoms of hypotension or a systolic blood pressure of less than 95 mm Hg, Severe CKD and an estimated glomerular filtration rate (eGFR) below 30 ml per minute per 1.73 m2 of body-surface area or rapidly declining renal function Inability to give informed consent
Sites / Locations
- Damanhour Teaching Hospital, General Organization for Teaching Hospitals and Institutes.Recruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Diabetic/HFrEF Group
Nondiabetic/HFrEF Group
40 patients with diabetes mellitus patients will be divided into 2 subgroups one on Empagliflozin and the other one on Dapagliflozin.
40 patients non-diabetes mellitus group will be divided into 2 subgroups one on Empagliflozin and the other one on Dapagliflozin.