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A Research Study to See How Well CagriSema Compared to Semaglutide, Cagrilintide and Placebo Lowers Blood Sugar and Body Weight in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor (REIMAGINE 2)

Primary Purpose

Type 2 Diabetes Mellitus

Status

Recruiting

Phase

Phase 3

Locations

International

Study Type

Interventional

Intervention

Cagrilintide

Semaglutide

Placebo cagrilintide

Placebo semaglutide

About this trial

This is an interventional treatment trial for Type 2 Diabetes Mellitus

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria: Male or female. Age 18 years or above at the time of signing the informed consent. Diagnosed with type 2 diabetes mellitus greater than or equal to 180 days before screening. Stable daily dose(s) greater than or equal to 90 days before screening of any of the following antidiabetic drug(s) or combination regimen(s) at effective or maximum tolerated dose as judged by the investigator: metformin with or without Sodium-Glucose Cotransporter-2 (SGLT2) inhibitors. Glycated haemoglobin (HbA1c) 7.0-10.5 percent (53-91 millimoles per mole [mmol/mol]) (both inclusive) as determined by central laboratory at screening. Body Mass Index (BMI) greater than or equal to 25 kilogram per square metre ( kg/m^2) at screening. BMI will be calculated in the electronic case report form (eCRF) based on height and body weight at screening. Exclusion Criteria: Renal impairment with estimated Glomerular Filtration Rate (eGFR) less than 30 milliliters per minute per 1.73 square metre (mL/min/1.73 m^2) as determined by central laboratory at screening. Treatment with any medication for the indication of diabetes or obesity other than stated in the inclusion criteria within 90 days before screening. However, short term insulin treatment for a maximum of 14 consecutive days and prior insulin treatment for gestational diabetes are allowed. Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verified by a fundus examination performed within 90 days before screening or in the period between screening and randomisation.

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm 5

Arm 6

Arm 7

Arm Type

Experimental

Active Comparator

Placebo Comparator

Arm Label

CagriSema 2.4 mg/2.4 mg

CagriSema 1.0 mg/1.0 mg

Semaglutide 2.4 mg

Semaglutide 1.0 mg

Cagrilintide 2.4 mg

Placebo 2.4 mg/2.4 mg

Placebo 1.0 mg/1.0 mg

Arm Description

Participants will receive once-weekly subcutaneous (s.c) injections of 2.4 mg cagrilintide and 2.4 mg semaglutide for 68 weeks.

Participants will receive once-weekly s.c injections of 1.0 mg cagrilintide and 1.0 mg semaglutide for 68 weeks.

Participants will receive once-weekly s.c injection of 2.4 mg semaglutide for 68 weeks.

Participants will receive once-weekly s.c injection of 1.0 mg semaglutide for 68 weeks.

Participants will receive once-weekly s.c injection of 2.4 mg cagrilintide for 68 weeks.

Participants will receive once-weekly s.c injection of placebo matched to 2.4 mg cagrilintide and 2.4 mg semaglutide for 68 weeks.

Participants will receive once-weekly s.c injection of placebo matched to 1.0 mg cagrilintide and 1.0 mg semaglutide for 68 weeks.

Outcomes

Primary Outcome Measures

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg versus 1.0 mg): Change in glycated haemoglobin (HbA1c)

Measured in percentage-points.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg versus 1.0 mg): Relative change in body weight

Measured in percentage.

Secondary Outcome Measures

CagriSema 2.4 mg/2.4 mg versus cagrilintide 2.4 mg: Change in HbA1c

Measured in percentage-points.

CagriSema 2.4 mg/2.4 mg versus cagrilintide 2.4 mg: Relative change in body weight

Measured in percentage.

CagriSema 2.4 mg/2.4 mg versus semaglutide 1.0 mg: Change in HbA1c

Measured in percentage-points.

CagriSema 2.4 mg/2.4 mg versus semaglutide 1.0 mg: Relative change in body weight

Measured in percentage.

Cagrilintide 2.4 mg versus placebo: Change in HbA1c

Measured in percentage-points.

Cagrilintide 2.4 mg versus placebo: Relative change in body weight

Measured in percentage.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Achievement of greater than or equal to (>=) 10 percent (%) weight reduction

Measured as count of participants.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Achievement of >= 15 % weight reduction

Measured as count of participants.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Achievement of >= 20 % weight reduction

Measured as count of participants.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): CGM - Change in time in Tight Target Range (TITR) 3.9-7.8 millimoles per litre (mmol/L) (70-140 milligrams per decilitre [mg/dL])

Measured in percentage-points.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Change in Systolic Blood Pressure (SBP)

Measured in millimeters of mercury (mmHg).

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Ratio to baseline in triglycerides

Measured as ratio of triglycerides.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Ratio to baseline in non-High Density Lipoprotein (HDL) cholesterols

Measured as ratio of non-HDL cholesterol.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): CGM - Change in Time In Range (TIR) 3.9-10.0 mmol/L (70-180 mg/dL)

Measured in percentage-points.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Ratio to baseline in high sensitivity C-Reactive Protein (hsCRP)

Measured as ratio of hsCRP.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Change in Fasting Plasma Glucose (FPG)

Measured in mmol/L.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Achievement of HbA1c target values of less than (<) 7.0% (<53 millimoles per mole [mmol/mol])

Measured as count of participants.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Achievement of HbA1c target values of less than or equal to (≤)6.5% (≤48 mmol/mol)

Measured as count of participants.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): CGM - Change in time above range, >10.0 mmol/L (>180 mg/dL)

Measured in percentage-points.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): CGM - Change in time above range, >13.9 mmol/L (>250 mg/dL)

Measured in percentage-points.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): CGM - Within-day glycaemic variability (% coefficient of variation [CV])

Measured in percentage.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg versus 1.0 mg): Achievement of ≥ 5 % weight reduction

Measured as count of participants.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Change in waist circumference

Measured in centimetre.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Change in Diastolic Blood Pressure (DBP)

Measured in mmHg.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Ratio to baseline in total cholesterol

Measured as ratio of total cholesterol.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Ratio to baseline in HDL cholesterol

Measured as ratio of HDL cholesterol.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Ratio to baseline in low-density lipoprotein (LDL) cholesterol

Measured as ratio of LDL cholesterol.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Ratio to baseline in very low-density lipoprotein (VLDL) cholesterol

Measured as ratio of VLDL.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Ratio to baseline in free fatty acids

Measured as ratio of free fatty acids.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Change in Short Form (SF)-36v score- Physical component summary score

SF-36v2 measure consists of 36 items yielding 8 health domain scores and 2 component summary scores. SF-36v2 acute scores are norm-based scores, i.e. transformed to a scale where the 2009 US general population has a mean of 50 and an standard deviation of 10. Physical component summary score range from 6.1 to 79.7, with higher scores indicating better functional health and well-being.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Change in SF-36v2 score- Mental component summary score

SF-36v2 measure consists of 36 items yielding 8 health domain scores and 2 component summary scores. SF-36v2 acute scores are norm-based scores, i.e. transformed to a scale where the 2009 US general population has a mean of 50 and an standard deviation of 10. Mental component summary score range from -3.8 to 78.7, with higher scores indicating better functional health and well-being.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Change in Diabetes Treatment Satisfaction Questionnaire (DTSQ) score

DTSQc measures treatment satisfaction and diabetes-specific quality of life (QoL). The measure consists of 8 items yielding 1 global score and 2 single item scores. Total treatment satisfaction scores range from 0-36, with higher scores indicating greater satisfaction; the perceived frequency of hyperglycemia/hypoglycemia items are scored separately, with lower scores indicating better perceived blood glucose control.

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Change in Treatment Related Impact Measure for Diabetes (TRIM-D) score

TRIM-D measures impact of diabetes treatment. The measure consists of 28 items yielding 5 domain scores and a total score. The scores were transformed to a 0-100 scale with higher scores indicating a better health state.

CagriSema (2.4 mg/2.4 mg and 1.0 mg/1.0 mg) versus semaglutide (2.4 mg and 1.0 mg), placebo and cagrilintide 2.4 mg: Number of treatment emergent adverse events (TEAEs)

Measured as count of events.

CagriSema (2.4 mg/2.4 mg and 1.0 mg/1.0 mg) versus semaglutide (2.4 mg and 1.0 mg), placebo and cagrilintide 2.4 mg: Number of clinically significant hypoglycaemic episodes (level 2) (<3.0 mmol/L (54 mg/dL), confirmed by BG meter)

Measured as count of episodes.

CagriSema (2.4 mg/2.4 mg and 1.0 mg/1.0 mg) versus semaglutide (2.4 mg and 1.0 mg), placebo and cagrilintide 2.4 mg: Number of severe hypoglycaemic episodes (level 3)

Measured as count of episodes. Hypoglycaemia episodes (level 3) are the episodes associated with severe cognitive impairment requiring external assistance for recovery, with no specific glucose threshold.

Full Information

NCT ID

NCT06065540

First Posted

September 26, 2023

Last Updated

October 17, 2023

Sponsor

Novo Nordisk A/S

1. Study Identification

Unique Protocol Identification Number

NCT06065540

Brief Title

A Research Study to See How Well CagriSema Compared to Semaglutide, Cagrilintide and Placebo Lowers Blood Sugar and Body Weight in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor

Acronym

REIMAGINE 2

Official Title

Efficacy and Safety of Co-administered Cagrilintide and Semaglutide (CagriSema) s.c. in Doses 2.4/2.4 mg and 1.0/1.0 mg Once Weekly Versus Semaglutide 2.4 mg and 1.0 mg, Cagrilintide 2.4 mg and Placebo in Participants With Type 2 Diabetes Inadequately Controlled on Metformin With or Without an SGLT2 Inhibitor

Study Type

Interventional

2. Study Status

Record Verification Date

October 2023

Overall Recruitment Status

Recruiting

Study Start Date

September 27, 2023 (Actual)

Primary Completion Date

November 26, 2025 (Anticipated)

Study Completion Date

January 14, 2026 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

Novo Nordisk A/S

4. Oversight

Studies a U.S. FDA-regulated Drug Product

Yes

Studies a U.S. FDA-regulated Device Product

Data Monitoring Committee

5. Study Description

Brief Summary

The study will look at how well CagriSema helps people lower their blood sugar and body weight. CagriSema is a new weekly medicine that combines two medicines called semaglutide and cagrilintide. CagriSema will be compared to the two medicines semaglutide and cagrilintide, when they are taken alone. CagriSema will also be compared to a "dummy" medicine without any active ingredient. The study will be done in participants who have type 2 diabetes. Participants will take the study medicine together with the current diabetes medicine (metformin with or without an SGLT2 inhibitor).

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Type 2 Diabetes Mellitus

7. Study Design

Primary Purpose

Treatment

Study Phase

Phase 3

Interventional Study Model

Parallel Assignment

Masking

ParticipantCare ProviderInvestigatorOutcomes Assessor

Masking Description

Sponsor staff involved in the clinical trial is masked according to company standard procedures.

Allocation

Randomized

Enrollment

2700 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title

CagriSema 2.4 mg/2.4 mg

Arm Type

Experimental

Arm Description

Participants will receive once-weekly subcutaneous (s.c) injections of 2.4 mg cagrilintide and 2.4 mg semaglutide for 68 weeks.

Arm Title

CagriSema 1.0 mg/1.0 mg

Arm Type

Experimental

Arm Description

Participants will receive once-weekly s.c injections of 1.0 mg cagrilintide and 1.0 mg semaglutide for 68 weeks.

Arm Title

Semaglutide 2.4 mg

Arm Type

Active Comparator

Arm Description

Participants will receive once-weekly s.c injection of 2.4 mg semaglutide for 68 weeks.

Arm Title

Semaglutide 1.0 mg

Arm Type

Active Comparator

Arm Description

Participants will receive once-weekly s.c injection of 1.0 mg semaglutide for 68 weeks.

Arm Title

Cagrilintide 2.4 mg

Arm Type

Active Comparator

Arm Description

Participants will receive once-weekly s.c injection of 2.4 mg cagrilintide for 68 weeks.

Arm Title

Placebo 2.4 mg/2.4 mg

Arm Type

Placebo Comparator

Arm Description

Participants will receive once-weekly s.c injection of placebo matched to 2.4 mg cagrilintide and 2.4 mg semaglutide for 68 weeks.

Arm Title

Placebo 1.0 mg/1.0 mg

Arm Type

Placebo Comparator

Arm Description

Participants will receive once-weekly s.c injection of placebo matched to 1.0 mg cagrilintide and 1.0 mg semaglutide for 68 weeks.

Intervention Type

Drug

Intervention Name(s)

Cagrilintide

Intervention Description

Participants will receive once-weekly s.c injection of cagrilintide at escalating doses every week until maintenance dose of 2.4 mg and 1.0 mg of cagrilintide is reached.

Intervention Type

Drug

Intervention Name(s)

Semaglutide

Intervention Description

Participants will receive once-weekly s.c injection of semaglutide at escalating doses every week until maintenance dose of 2.4 mg and 1.0 mg of semaglutide is reached.

Intervention Type

Drug

Intervention Name(s)

Placebo cagrilintide

Intervention Description

Participants will receive placebo matched to cagrilintide subcutaneously.

Intervention Type

Drug

Intervention Name(s)

Placebo semaglutide

Intervention Description

Participants will receive placebo matched to semaglutide subcutaneously.

Primary Outcome Measure Information:

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg versus 1.0 mg): Change in glycated haemoglobin (HbA1c)

Description

Measured in percentage-points.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg versus 1.0 mg): Relative change in body weight

Description

Measured in percentage.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Secondary Outcome Measure Information:

Title

CagriSema 2.4 mg/2.4 mg versus cagrilintide 2.4 mg: Change in HbA1c

Description

Measured in percentage-points.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema 2.4 mg/2.4 mg versus cagrilintide 2.4 mg: Relative change in body weight

Description

Measured in percentage.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema 2.4 mg/2.4 mg versus semaglutide 1.0 mg: Change in HbA1c

Description

Measured in percentage-points.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema 2.4 mg/2.4 mg versus semaglutide 1.0 mg: Relative change in body weight

Description

Measured in percentage.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

Cagrilintide 2.4 mg versus placebo: Change in HbA1c

Description

Measured in percentage-points.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

Cagrilintide 2.4 mg versus placebo: Relative change in body weight

Description

Measured in percentage.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Achievement of greater than or equal to (>=) 10 percent (%) weight reduction

Description

Measured as count of participants.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Achievement of >= 15 % weight reduction

Description

Measured as count of participants.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Achievement of >= 20 % weight reduction

Description

Measured as count of participants.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

Description

Measured in percentage-points.

Time Frame

From baseline (week -3) to end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Change in Systolic Blood Pressure (SBP)

Description

Measured in millimeters of mercury (mmHg).

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Ratio to baseline in triglycerides

Description

Measured as ratio of triglycerides.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Ratio to baseline in non-High Density Lipoprotein (HDL) cholesterols

Description

Measured as ratio of non-HDL cholesterol.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): CGM - Change in Time In Range (TIR) 3.9-10.0 mmol/L (70-180 mg/dL)

Description

Measured in percentage-points.

Time Frame

From baseline (week -3) to end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Ratio to baseline in high sensitivity C-Reactive Protein (hsCRP)

Description

Measured as ratio of hsCRP.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Change in Fasting Plasma Glucose (FPG)

Description

Measured in mmol/L.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Achievement of HbA1c target values of less than (<) 7.0% (<53 millimoles per mole [mmol/mol])

Description

Measured as count of participants.

Time Frame

At end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Achievement of HbA1c target values of less than or equal to (≤)6.5% (≤48 mmol/mol)

Description

Measured as count of participants.

Time Frame

At end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): CGM - Change in time above range, >10.0 mmol/L (>180 mg/dL)

Description

Measured in percentage-points.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): CGM - Change in time above range, >13.9 mmol/L (>250 mg/dL)

Description

Measured in percentage-points.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): CGM - Within-day glycaemic variability (% coefficient of variation [CV])

Description

Measured in percentage.

Time Frame

At end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg versus 1.0 mg): Achievement of ≥ 5 % weight reduction

Description

Measured as count of participants.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Change in waist circumference

Description

Measured in centimetre.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Change in Diastolic Blood Pressure (DBP)

Description

Measured in mmHg.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Ratio to baseline in total cholesterol

Description

Measured as ratio of total cholesterol.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Ratio to baseline in HDL cholesterol

Description

Measured as ratio of HDL cholesterol.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Ratio to baseline in low-density lipoprotein (LDL) cholesterol

Description

Measured as ratio of LDL cholesterol.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Ratio to baseline in very low-density lipoprotein (VLDL) cholesterol

Description

Measured as ratio of VLDL.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Ratio to baseline in free fatty acids

Description

Measured as ratio of free fatty acids.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Change in Short Form (SF)-36v score- Physical component summary score

Description

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Change in SF-36v2 score- Mental component summary score

Description

SF-36v2 measure consists of 36 items yielding 8 health domain scores and 2 component summary scores. SF-36v2 acute scores are norm-based scores, i.e. transformed to a scale where the 2009 US general population has a mean of 50 and an standard deviation of 10. Mental component summary score range from -3.8 to 78.7, with higher scores indicating better functional health and well-being.

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Change in Diabetes Treatment Satisfaction Questionnaire (DTSQ) score

Description

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema versus semaglutide (2.4 mg/2.4 mg versus 2.4 mg and 1.0 mg/1.0 mg vs 1.0 mg): Change in Treatment Related Impact Measure for Diabetes (TRIM-D) score

Description

Time Frame

From baseline (week 0) to end of treatment (week 68)

Title

CagriSema (2.4 mg/2.4 mg and 1.0 mg/1.0 mg) versus semaglutide (2.4 mg and 1.0 mg), placebo and cagrilintide 2.4 mg: Number of treatment emergent adverse events (TEAEs)

Description

Measured as count of events.

Time Frame

From baseline (week 0) to end of study (week 75)

Title

Description

Measured as count of episodes.

Time Frame

From baseline (week 0) to end of study (week 75)

Title

CagriSema (2.4 mg/2.4 mg and 1.0 mg/1.0 mg) versus semaglutide (2.4 mg and 1.0 mg), placebo and cagrilintide 2.4 mg: Number of severe hypoglycaemic episodes (level 3)

Description

Time Frame

From baseline (week 0) to end of study (week 75)

10. Eligibility

Sex

All

Minimum Age & Unit of Time

18 Years

Accepts Healthy Volunteers

Eligibility Criteria

Central Contact Person:

First Name & Middle Initial & Last Name or Official Title & Degree

Novo Nordisk

Phone

(+1) 866-867-7178

clinicaltrials@novonordisk.com

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Clinical Transparency (dept. 2834)

Organizational Affiliation

Novo Nordisk A/S

Official's Role

Study Director

Facility Information:

Facility Name

Novo Nordisk Investigational Site

City

Birmingham

State/Province

Alabama

ZIP/Postal Code

35211

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Birmingham

State/Province

Alabama

ZIP/Postal Code

35294

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Pelham

State/Province

Alabama

ZIP/Postal Code

35124

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Phoenix

State/Province

Arizona

ZIP/Postal Code

85006

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Phoenix

State/Province

Arizona

ZIP/Postal Code

85020

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Little Rock

State/Province

Arkansas

ZIP/Postal Code

72205

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Banning

State/Province

California

ZIP/Postal Code

92220

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Chula Vista

State/Province

California

ZIP/Postal Code

91911

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Concord

State/Province

California

ZIP/Postal Code

94520

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Escondido

State/Province

California

ZIP/Postal Code

92025

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Gardena

State/Province

California

ZIP/Postal Code

90247

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

La Mesa

State/Province

California

ZIP/Postal Code

91942

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Loma Linda

State/Province

California

ZIP/Postal Code

92354

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Mission Hills

State/Province

California

ZIP/Postal Code

91345

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Palm Springs

State/Province

California

ZIP/Postal Code

92262

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Panorama City

State/Province

California

ZIP/Postal Code

91402

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

San Diego

State/Province

California

ZIP/Postal Code

92111

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Santa Ana

State/Province

California

ZIP/Postal Code

92704

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Toluca Lake

State/Province

California

ZIP/Postal Code

91602

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Colorado Springs

State/Province

Colorado

ZIP/Postal Code

80906

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Jacksonville

State/Province

Florida

ZIP/Postal Code

32204

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33144

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33155

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33165

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Miramar

State/Province

Florida

ZIP/Postal Code

33027

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Ocoee

State/Province

Florida

ZIP/Postal Code

34761

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Orange City

State/Province

Florida

ZIP/Postal Code

32763

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Orlando

State/Province

Florida

ZIP/Postal Code

32804

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Orlando

State/Province

Florida

ZIP/Postal Code

32806

Country

United States

Individual Site Status

Withdrawn

Facility Name

Novo Nordisk Investigational Site

City

Oviedo

State/Province

Florida

ZIP/Postal Code

32765

Country

United States

Individual Site Status

Withdrawn

Facility Name

Novo Nordisk Investigational Site

City

Conyers

State/Province

Georgia

ZIP/Postal Code

30094

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Macon

State/Province

Georgia

ZIP/Postal Code

31210

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Marietta

State/Province

Georgia

ZIP/Postal Code

30067

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Roswell

State/Province

Georgia

ZIP/Postal Code

30076

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Roswell

State/Province

Georgia

ZIP/Postal Code

30076

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96813

Country

United States

Individual Site Status

Withdrawn

Facility Name

Novo Nordisk Investigational Site

City

Boise

State/Province

Idaho

ZIP/Postal Code

83702

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Meridian

State/Province

Idaho

ZIP/Postal Code

83646

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60607

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Gurnee

State/Province

Illinois

ZIP/Postal Code

60031

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Skokie

State/Province

Illinois

ZIP/Postal Code

60077

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

West Des Moines

State/Province

Iowa

ZIP/Postal Code

50265

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Newton

State/Province

Kansas

ZIP/Postal Code

67114

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Topeka

State/Province

Kansas

ZIP/Postal Code

66606

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Lafayette

State/Province

Louisiana

ZIP/Postal Code

70508

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

New Bedford

State/Province

Massachusetts

ZIP/Postal Code

02740

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Gulfport

State/Province

Mississippi

ZIP/Postal Code

39503

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Chesterfield

State/Province

Missouri

ZIP/Postal Code

63017

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Trenton

State/Province

New Jersey

ZIP/Postal Code

08611

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Albuquerque

State/Province

New Mexico

ZIP/Postal Code

87107

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Albany

State/Province

New York

ZIP/Postal Code

12203

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

East Syracuse

State/Province

New York

ZIP/Postal Code

13057

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

West Seneca

State/Province

New York

ZIP/Postal Code

14224

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Westfield

State/Province

New York

ZIP/Postal Code

14787

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Chapel Hill

State/Province

North Carolina

ZIP/Postal Code

27514

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Greensboro

State/Province

North Carolina

ZIP/Postal Code

27408

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Morehead City

State/Province

North Carolina

ZIP/Postal Code

28557

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Statesville

State/Province

North Carolina

ZIP/Postal Code

28625

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Wilmington

State/Province

North Carolina

ZIP/Postal Code

28401

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Dublin

State/Province

Ohio

ZIP/Postal Code

43016

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Norman

State/Province

Oklahoma

ZIP/Postal Code

73069

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Cumberland

State/Province

Rhode Island

ZIP/Postal Code

02864

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

East Greenwich

State/Province

Rhode Island

ZIP/Postal Code

02818

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Anderson

State/Province

South Carolina

ZIP/Postal Code

29621

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Anderson

State/Province

South Carolina

ZIP/Postal Code

29621

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Gaffney

State/Province

South Carolina

ZIP/Postal Code

29340

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Simpsonville

State/Province

South Carolina

ZIP/Postal Code

29681-1538

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Spartanburg

State/Province

South Carolina

ZIP/Postal Code

29303

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Bristol

State/Province

Tennessee

ZIP/Postal Code

37620-7352

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Kingsport

State/Province

Tennessee

ZIP/Postal Code

37660

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Nashville

State/Province

Tennessee

ZIP/Postal Code

37203

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Arlington

State/Province

Texas

ZIP/Postal Code

76012-4637

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Bellaire

State/Province

Texas

ZIP/Postal Code

77401

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Cedar Park

State/Province

Texas

ZIP/Postal Code

78613

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Dallas

State/Province

Texas

ZIP/Postal Code

75230

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Dallas

State/Province

Texas

ZIP/Postal Code

75231

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Dallas

State/Province

Texas

ZIP/Postal Code

75234

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Dallas

State/Province

Texas

ZIP/Postal Code

75251

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Houston

State/Province

Texas

ZIP/Postal Code

77040

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Houston

State/Province

Texas

ZIP/Postal Code

77061

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Houston

State/Province

Texas

ZIP/Postal Code

77079

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Katy

State/Province

Texas

ZIP/Postal Code

77450

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Kerrville

State/Province

Texas

ZIP/Postal Code

78028

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78229

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78229

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78233

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Shavano Park

State/Province

Texas

ZIP/Postal Code

78231

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Tomball

State/Province

Texas

ZIP/Postal Code

77375

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Sandy

State/Province

Utah

ZIP/Postal Code

84093

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

West Jordan

State/Province

Utah

ZIP/Postal Code

84088

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Newport News

State/Province

Virginia

ZIP/Postal Code

23606

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Renton

State/Province

Washington

ZIP/Postal Code

98057

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Green Bay

State/Province

Wisconsin

ZIP/Postal Code

54303

Country

United States

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Caba

State/Province

Buenos Aires

ZIP/Postal Code

C1128 AAF

Country

Argentina

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Rosario

State/Province

Santa Fe

ZIP/Postal Code

S2000CUD

Country

Argentina

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Buenos Aires

ZIP/Postal Code

C1023AAB

Country

Argentina

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Buenos Aires

ZIP/Postal Code

C1425AGC

Country

Argentina

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Caba

ZIP/Postal Code

C1061AAS.

Country

Argentina

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Caba

ZIP/Postal Code

C1180AAX

Country

Argentina

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Camperdown

State/Province

New South Wales

ZIP/Postal Code

2050

Country

Australia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Darlinghurst

State/Province

New South Wales

ZIP/Postal Code

2010

Country

Australia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Macquarie Park

State/Province

New South Wales

ZIP/Postal Code

2109

Country

Australia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Merewether

State/Province

New South Wales

ZIP/Postal Code

2291

Country

Australia

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Meadowbrook

State/Province

Queensland

ZIP/Postal Code

4131

Country

Australia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Oaklands Park

State/Province

South Australia

ZIP/Postal Code

5046

Country

Australia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Fitzroy

State/Province

Victoria

ZIP/Postal Code

3065

Country

Australia

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Melbourne

State/Province

Victoria

ZIP/Postal Code

3004

Country

Australia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Curitiba

State/Province

Parana

ZIP/Postal Code

80030-480

Country

Brazil

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

São Paulo

State/Province

Sao Paulo

ZIP/Postal Code

01228-000

Country

Brazil

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

São Paulo

State/Province

Sao Paulo

ZIP/Postal Code

01228-200

Country

Brazil

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Burgas

ZIP/Postal Code

8000

Country

Bulgaria

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Gotse Delchev

ZIP/Postal Code

2900

Country

Bulgaria

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Kardzhali

ZIP/Postal Code

6600

Country

Bulgaria

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Lom

ZIP/Postal Code

3600

Country

Bulgaria

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Razgrad

ZIP/Postal Code

7200

Country

Bulgaria

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Sofia

ZIP/Postal Code

1202

Country

Bulgaria

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Sofia

ZIP/Postal Code

1756

Country

Bulgaria

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Varna

ZIP/Postal Code

9000

Country

Bulgaria

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Varna

ZIP/Postal Code

9010

Country

Bulgaria

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Calgary

State/Province

Alberta

ZIP/Postal Code

T2H 2G4

Country

Canada

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Sherwood Park

State/Province

Alberta

ZIP/Postal Code

T8H 0N2

Country

Canada

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Surrey

State/Province

British Columbia

ZIP/Postal Code

V3Z 2N6

Country

Canada

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Moncton

State/Province

New Brunswick

ZIP/Postal Code

E1G 1A7

Country

Canada

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Barrie

State/Province

Ontario

ZIP/Postal Code

L4N 7L3

Country

Canada

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Brampton

State/Province

Ontario

ZIP/Postal Code

L6S 0C6

Country

Canada

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Concord

State/Province

Ontario

ZIP/Postal Code

L4K 4M2

Country

Canada

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Etobicoke

State/Province

Ontario

ZIP/Postal Code

M9R 4E1

Country

Canada

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

London

State/Province

Ontario

ZIP/Postal Code

N5W 6A2

Country

Canada

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

London

State/Province

Ontario

ZIP/Postal Code

N6G 2M1

Country

Canada

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Markham

State/Province

Ontario

ZIP/Postal Code

L3P 7P2

Country

Canada

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Nepean

State/Province

Ontario

ZIP/Postal Code

K2J 0V2

Country

Canada

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Oshawa

State/Province

Ontario

ZIP/Postal Code

L1G4T3

Country

Canada

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Oshawa

State/Province

Ontario

ZIP/Postal Code

L1J 2K9

Country

Canada

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Toronto

State/Province

Ontario

ZIP/Postal Code

M4G 3E8

Country

Canada

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Toronto

State/Province

Ontario

ZIP/Postal Code

M6G 1M2

Country

Canada

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H4N 2W2

Country

Canada

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Pointe-Claire

State/Province

Quebec

ZIP/Postal Code

H9R 4S3

Country

Canada

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Saint-Laurent

State/Province

Quebec

ZIP/Postal Code

H4T 1Z9

Country

Canada

Individual Site Status

Withdrawn

Facility Name

Novo Nordisk Investigational Site

City

Sherbrooke

State/Province

Quebec

ZIP/Postal Code

J1J 2G2

Country

Canada

Individual Site Status

Withdrawn

Facility Name

Novo Nordisk Investigational Site

City

Terrebonne

State/Province

Quebec

ZIP/Postal Code

J6X 4P7

Country

Canada

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Quebec

ZIP/Postal Code

G1V 4T3

Country

Canada

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Quebec

ZIP/Postal Code

G1V 4W2

Country

Canada

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Beijing

State/Province

Beijing

ZIP/Postal Code

100050

Country

China

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Beijing

State/Province

Beijing

ZIP/Postal Code

100853

Country

China

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Chongqing

State/Province

Chongqing

ZIP/Postal Code

404000

Country

China

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Kaifeng

State/Province

Henan

ZIP/Postal Code

450000

Country

China

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Nanjing

State/Province

Jiangsu

ZIP/Postal Code

210011

Country

China

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Suzhou

State/Province

Jiangsu

ZIP/Postal Code

215002

Country

China

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Zhenjiang

State/Province

Jiangsu

ZIP/Postal Code

212001

Country

China

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Ji'Nan

State/Province

Shandong

ZIP/Postal Code

250000

Country

China

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Floridablanca

State/Province

Santander

ZIP/Postal Code

681004

Country

Colombia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Barranquilla

ZIP/Postal Code

80001

Country

Colombia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Cali

ZIP/Postal Code

760042

Country

Colombia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Monteria

ZIP/Postal Code

230001

Country

Colombia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Zagreb

State/Province

Grad Zagreb

ZIP/Postal Code

10000

Country

Croatia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Osijek

State/Province

Osječko - Baranjska Županija

ZIP/Postal Code

31000

Country

Croatia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Rijeka

State/Province

Primorsko - Goranska Županija

ZIP/Postal Code

51 000

Country

Croatia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Opatija

ZIP/Postal Code

51 410

Country

Croatia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Slavonski Brod

ZIP/Postal Code

35 000

Country

Croatia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Varazdin

ZIP/Postal Code

42 000

Country

Croatia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Praha 4

State/Province

Czech Republic

ZIP/Postal Code

140 21

Country

Czechia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Brno

ZIP/Postal Code

602 00

Country

Czechia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Broumov

ZIP/Postal Code

550 01

Country

Czechia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Holešov

ZIP/Postal Code

76901

Country

Czechia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Plzeň 3

ZIP/Postal Code

301 00

Country

Czechia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Praha 1

ZIP/Postal Code

110 00

Country

Czechia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Praha 4

ZIP/Postal Code

140 00

Country

Czechia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Aarhus N

ZIP/Postal Code

8200

Country

Denmark

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Herlev

ZIP/Postal Code

2730

Country

Denmark

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Hillerød

ZIP/Postal Code

3400

Country

Denmark

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Hvidovre

ZIP/Postal Code

2650

Country

Denmark

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

København

ZIP/Postal Code

2400

Country

Denmark

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Odense C

ZIP/Postal Code

5000

Country

Denmark

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Jyväskylä

ZIP/Postal Code

40100

Country

Finland

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Seinäjoki

ZIP/Postal Code

60220

Country

Finland

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Tampere

ZIP/Postal Code

33100

Country

Finland

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Turku

ZIP/Postal Code

20520

Country

Finland

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Berlin

ZIP/Postal Code

13597

Country

Germany

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Daaden

ZIP/Postal Code

57567

Country

Germany

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Dortmund

ZIP/Postal Code

44137

Country

Germany

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Dresden

ZIP/Postal Code

01307

Country

Germany

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Elsterwerda

ZIP/Postal Code

04910

Country

Germany

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Essen

ZIP/Postal Code

45136

Country

Germany

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Gelnhausen

ZIP/Postal Code

63571

Country

Germany

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Hamburg

ZIP/Postal Code

21109

Country

Germany

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Hamburg

ZIP/Postal Code

22041

Country

Germany

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Lingen

ZIP/Postal Code

49808

Country

Germany

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Ludwigshafen

ZIP/Postal Code

67059

Country

Germany

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Lübeck

ZIP/Postal Code

23562

Country

Germany

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

München

ZIP/Postal Code

81667

Country

Germany

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Oldenburg in Holstein

ZIP/Postal Code

23758

Country

Germany

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Zwenkau

ZIP/Postal Code

04442

Country

Germany

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Nea Efkarpia

State/Province

Thessaloniki

ZIP/Postal Code

56429

Country

Greece

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Athens

ZIP/Postal Code

115 25

Country

Greece

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Athens

ZIP/Postal Code

GR-11527

Country

Greece

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Athens

ZIP/Postal Code

GR-15125

Country

Greece

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Haidari-Athens

ZIP/Postal Code

GR-12462

Country

Greece

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Larissa

ZIP/Postal Code

GR-41110

Country

Greece

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Thessaloniki

ZIP/Postal Code

54636

Country

Greece

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Thessaloniki

ZIP/Postal Code

GR-54621

Country

Greece

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Thessaloniki

ZIP/Postal Code

GR-54642

Country

Greece

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Thessaloniki

ZIP/Postal Code

GR-54643

Country

Greece

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Szeged

State/Province

Csongrád-Csanád

ZIP/Postal Code

H-6725

Country

Hungary

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Debrecen

State/Province

Hajdu-Bihar

ZIP/Postal Code

4032

Country

Hungary

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Budapest

ZIP/Postal Code

1036

Country

Hungary

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Budapest

ZIP/Postal Code

1106

Country

Hungary

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Budapest

ZIP/Postal Code

1134

Country

Hungary

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Kaposvár

ZIP/Postal Code

7400

Country

Hungary

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Nagykanizsa

ZIP/Postal Code

8800

Country

Hungary

Individual Site Status

Withdrawn

Facility Name

Novo Nordisk Investigational Site

City

Szombathely

ZIP/Postal Code

H-9700

Country

Hungary

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Zalaegerszeg

ZIP/Postal Code

8900

Country

Hungary

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Vijaywada

State/Province

Andhra Pradesh

ZIP/Postal Code

520002

Country

India

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Guwahati

State/Province

Assam

ZIP/Postal Code

781032

Country

India

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Bengaluru

State/Province

Karnataka

ZIP/Postal Code

560066

Country

India

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Mysuru

State/Province

Karnataka

ZIP/Postal Code

570001

Country

India

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Mumbai

State/Province

Maharashtra

ZIP/Postal Code

400008

Country

India

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Thane

State/Province

Maharashtra

ZIP/Postal Code

421004

Country

India

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Jaipur

State/Province

Rajasthan

ZIP/Postal Code

302004

Country

India

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Chennai

State/Province

Tamil Nadu

ZIP/Postal Code

600086

Country

India

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Coimbatore

State/Province

Tamil Nadu

ZIP/Postal Code

641018

Country

India

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Hyderabad

State/Province

Telangana

ZIP/Postal Code

500004

Country

India

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Hyderabad

State/Province

Telangana

ZIP/Postal Code

500072

Country

India

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Kolkata

State/Province

West Bengal

ZIP/Postal Code

700054

Country

India

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Ahmedabad

ZIP/Postal Code

390013

Country

India

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Chandigarh

ZIP/Postal Code

160012

Country

India

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

New Delhi

ZIP/Postal Code

110001

Country

India

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Haifa

ZIP/Postal Code

35152

Country

Israel

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Herzlia

ZIP/Postal Code

4630945

Country

Israel

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Holon

ZIP/Postal Code

58100

Country

Israel

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Jerusalem

ZIP/Postal Code

91120

Country

Israel

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Rehovot

ZIP/Postal Code

76100

Country

Israel

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Tel Hashomer

ZIP/Postal Code

52621

Country

Israel

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Firenze

State/Province

ZIP/Postal Code

50134

Country

Italy

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Milano

State/Province

ZIP/Postal Code

20132

Country

Italy

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Arezzo

ZIP/Postal Code

52100

Country

Italy

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Bergamo

ZIP/Postal Code

24127

Country

Italy

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Catanzaro

ZIP/Postal Code

88100

Country

Italy

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Chieti Scalo

ZIP/Postal Code

66100

Country

Italy

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Milano

ZIP/Postal Code

20157

Country

Italy

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Napoli

ZIP/Postal Code

80131

Country

Italy

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Palermo

ZIP/Postal Code

90127

Country

Italy

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Roma

ZIP/Postal Code

00161

Country

Italy

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Rome

ZIP/Postal Code

00168

Country

Italy

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Verona

ZIP/Postal Code

37126

Country

Italy

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Ibaraki

ZIP/Postal Code

311-0113

Country

Japan

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Osaka-shi, Osaka

ZIP/Postal Code

530-8480

Country

Japan

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Tokyo

ZIP/Postal Code

103-0027

Country

Japan

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Tokyo

ZIP/Postal Code

104-0031

Country

Japan

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Bucheon-si

State/Province

Gyeonggi-do

ZIP/Postal Code

14647

Country

Korea, Republic of

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Daegu

ZIP/Postal Code

42415

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Gwangju

ZIP/Postal Code

501-717

Country

Korea, Republic of

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Seoul

ZIP/Postal Code

02447

Country

Korea, Republic of

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Seoul

ZIP/Postal Code

02841

Country

Korea, Republic of

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Seoul

ZIP/Postal Code

03080

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Novo Nordisk Investigational Site

City

Seoul

ZIP/Postal Code

03181

Country

Korea, Republic of

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Mexicali

State/Province

Baja California

ZIP/Postal Code

21200

Country

Mexico

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Guadalajara

State/Province

Jalisco

ZIP/Postal Code

44600

Country

Mexico

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Guadalajara

State/Province

Jalisco

ZIP/Postal Code

44670

Country

Mexico

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Ciudad Madero

State/Province

Tamaulipas

ZIP/Postal Code

89440

Country

Mexico

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Lodz

State/Province

Lodzkie

ZIP/Postal Code

93-513

Country

Poland

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Gorzow Wielkopolski

State/Province

Lubuskie

ZIP/Postal Code

66-400

Country

Poland

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Rzeszow

State/Province

Malopolskie

ZIP/Postal Code

35-055

Country

Poland

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Żyrardów

State/Province

Masovian

ZIP/Postal Code

96-300

Country

Poland

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Warszawa

State/Province

Mazovian Voivodeship

ZIP/Postal Code

02-117

Country

Poland

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Bialystok

State/Province

Podlaskie

ZIP/Postal Code

15-435

Country

Poland

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Chrzanow

State/Province

Slaskie

ZIP/Postal Code

32-500

Country

Poland

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Dąbrowa-Górnicza

State/Province

Slaskie

ZIP/Postal Code

41-300

Country

Poland

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Tychy

State/Province

Slaskie

ZIP/Postal Code

43-100

Country

Poland

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Bialystok

ZIP/Postal Code

15-351

Country

Poland

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Lublin

ZIP/Postal Code

20-362

Country

Poland

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Pulawy

ZIP/Postal Code

24-100

Country

Poland

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Zgierz

ZIP/Postal Code

95-100

Country

Poland

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Staszow

State/Province

Świętokrzyskie

ZIP/Postal Code

28-200

Country

Poland

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Pitesti

State/Province

Arges

ZIP/Postal Code

110283

Country

Romania

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Bucharest

State/Province

Bucurestii

ZIP/Postal Code

020475

Country

Romania

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Cluj Napoca

State/Province

Cluj

ZIP/Postal Code

400006

Country

Romania

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Ploiesti

State/Province

Prahova

ZIP/Postal Code

100179

Country

Romania

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Ploiesti

State/Province

Prahova

ZIP/Postal Code

100342

Country

Romania

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Zalau

State/Province

Salaj

ZIP/Postal Code

450112

Country

Romania

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Bacau

ZIP/Postal Code

600154

Country

Romania

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Brasov

ZIP/Postal Code

500283

Country

Romania

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Bucuresti

ZIP/Postal Code

050913

Country

Romania

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Galati

ZIP/Postal Code

800001

Country

Romania

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Mangalia

ZIP/Postal Code

905500

Country

Romania

Individual Site Status

Withdrawn

Facility Name

Novo Nordisk Investigational Site

City

Pascani

ZIP/Postal Code

705200

Country

Romania

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Novi Sad

State/Province

Vojvodina

ZIP/Postal Code

21000

Country

Serbia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Belgrade

ZIP/Postal Code

11000

Country

Serbia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Belgrade

ZIP/Postal Code

11080

Country

Serbia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Kragujevac

ZIP/Postal Code

34000

Country

Serbia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Bardejov

ZIP/Postal Code

08501

Country

Slovakia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Kosice

ZIP/Postal Code

040 01

Country

Slovakia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Malacky

ZIP/Postal Code

90101

Country

Slovakia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Presov

ZIP/Postal Code

080 01

Country

Slovakia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Prievidza

ZIP/Postal Code

971 01

Country

Slovakia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Ruzomberok

ZIP/Postal Code

034 01

Country

Slovakia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Sabinov

ZIP/Postal Code

083 01

Country

Slovakia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Surany

ZIP/Postal Code

942 01

Country

Slovakia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Trebisov

ZIP/Postal Code

075 01

Country

Slovakia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Ziar nad Hronom

ZIP/Postal Code

965 01

Country

Slovakia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Kocevje

ZIP/Postal Code

1330

Country

Slovenia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Koper

ZIP/Postal Code

6000

Country

Slovenia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Ljubljana

ZIP/Postal Code

1000

Country

Slovenia

Individual Site Status

Withdrawn

Facility Name

Novo Nordisk Investigational Site

City

Ljubljana

ZIP/Postal Code

1000

Country

Slovenia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Maribor

ZIP/Postal Code

2000

Country

Slovenia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Nova Gorica

ZIP/Postal Code

5000

Country

Slovenia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Sempeter pri Gorici

ZIP/Postal Code

5290

Country

Slovenia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Topolšica

ZIP/Postal Code

3326

Country

Slovenia

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Port Elizabeth

State/Province

Eastern Cape

ZIP/Postal Code

6001

Country

South Africa

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Johannesburg

State/Province

Gauteng

ZIP/Postal Code

2001

Country

South Africa

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Johannesburg

State/Province

Gauteng

ZIP/Postal Code

2196

Country

South Africa

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Kempton Park

State/Province

Gauteng

ZIP/Postal Code

1619

Country

South Africa

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Pretoria

State/Province

Gauteng

ZIP/Postal Code

0186

Country

South Africa

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Paarl

State/Province

Western Cape

ZIP/Postal Code

7646

Country

South Africa

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Barcelona

ZIP/Postal Code

08035

Country

Spain

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

La Coruña

ZIP/Postal Code

15006

Country

Spain

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

La Roca del Vallés

ZIP/Postal Code

08430

Country

Spain

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Móstoles

ZIP/Postal Code

28935

Country

Spain

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Palma de Mallorca

ZIP/Postal Code

07198

Country

Spain

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Segovia

ZIP/Postal Code

40002

Country

Spain

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Sevilla

ZIP/Postal Code

41010

Country

Spain

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Valencia

ZIP/Postal Code

46026

Country

Spain

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Lund

ZIP/Postal Code

221 85

Country

Sweden

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Lund

ZIP/Postal Code

222 21

Country

Sweden

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Malmö

ZIP/Postal Code

205 02

Country

Sweden

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Stockholm

ZIP/Postal Code

171 76

Country

Sweden

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Örebro

ZIP/Postal Code

701 85

Country

Sweden

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Changhua City

ZIP/Postal Code

500

Country

Taiwan

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Taipei city

ZIP/Postal Code

110

Country

Taiwan

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Adana

ZIP/Postal Code

01130

Country

Turkey

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Antalya

ZIP/Postal Code

07058

Country

Turkey

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Eskisehir

ZIP/Postal Code

26040

Country

Turkey

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Istanbul

ZIP/Postal Code

34098

Country

Turkey

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Istanbul

ZIP/Postal Code

34371

Country

Turkey

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Istanbul

ZIP/Postal Code

34390

Country

Turkey

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Istanbul

ZIP/Postal Code

34480

Country

Turkey

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Istanbul

ZIP/Postal Code

34722

Country

Turkey

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Rize

ZIP/Postal Code

53020

Country

Turkey

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Tekirdag

ZIP/Postal Code

59030

Country

Turkey

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Stevenage

State/Province

Hertfordshire

ZIP/Postal Code

SG1 4AB

Country

United Kingdom

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Bath

ZIP/Postal Code

BA2 3HT

Country

United Kingdom

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Blackburn

ZIP/Postal Code

BB2 1AX

Country

United Kingdom

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Dundee

ZIP/Postal Code

DD1 9SY

Country

United Kingdom

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Foresterhill

ZIP/Postal Code

AB25 2ZP

Country

United Kingdom

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Liverpool

ZIP/Postal Code

L9 7AL

Country

United Kingdom

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Norwich

ZIP/Postal Code

NR4 7UY

Country

United Kingdom

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Pickering

ZIP/Postal Code

YO18 8BL

Country

United Kingdom

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Southampton

ZIP/Postal Code

SO30 3JB

Country

United Kingdom

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Swansea

ZIP/Postal Code

SA2 8PP

Country

United Kingdom

Individual Site Status

Not yet recruiting

Facility Name

Novo Nordisk Investigational Site

City

Truro

ZIP/Postal Code

TR1 3LJ

Country

United Kingdom

Individual Site Status

Not yet recruiting

12. IPD Sharing Statement

Plan to Share IPD

Yes

IPD Sharing Plan Description

According to the Novo Nordisk disclosure commitment on novonordisk-trials.com

IPD Sharing URL

http://novonordisk-trials.com

Learn more about this trial

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A Research Study to See How Well CagriSema Compared to Semaglutide, Cagrilintide and Placebo Lowers Blood Sugar and Body Weight in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor (REIMAGINE 2)

Type 2 Diabetes Mellitus

About this trial

Eligibility Criteria

Sites / Locations

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm 5

Arm 6

Arm 7

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

1. Study Identification

2. Study Status

3. Sponsor/Collaborators

4. Oversight

5. Study Description

6. Conditions and Keywords

7. Study Design

8. Arms, Groups, and Interventions

10. Eligibility

12. IPD Sharing Statement

Learn more about this trial