Efficacy of Phenytoin vs Levetiracetam in Status Epilepticus at Institute of Child Health,Faisalabad
Status Epilepticus
About this trial
This is an interventional treatment trial for Status Epilepticus focused on measuring Efficacy, Phenytoin, Levetiracetam
Eligibility Criteria
Inclusion Criteria Children with status Epilepticus i.e with continuous seizure of 5 min or more or two or more discrete seizures in which there is incomplete recovery of consciousness was included in this study. Convulsive states epilepticus, Generalized tonic clonic seizures, Focal tonic clonic seizures are included. Age:6 months to 12 years. Gender: Both genders. Exclusion Criteria: Participants on any antiepileptic drug (AED) or having allergic reaction towards phenytoin or Levetiracetam were excluded from the study. Non convulsive status epilepticus, Absence status epilepticus, Myoclonic status epilepticus were excluded.
Sites / Locations
- Children Hopsital Faisalabad
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
levetiracetam
phenytoin
levetiracetam at a dose of 30 mg/kg diluted in 50 ml of normal saline in 15 minutes followed by a maintenance dose of 30mg/kg/day divided in two doses 12 hours apart after initial loading dose. if seizures recurred after the first loading dose an additional 10mg/kg of the same drug was given over 10 minutes. If seizures recurred, the patients were loaded with sodium valporate 30 mg/kg diluted in 50 ml normal saline in 15 minutes.
I/V phenytoin at 20 mg/kg diluted in 50ml normal saline in 15 minutes followed by maintenance dose of 5 mg/kg/day divided in two doses 12 hours apart. if seizures recurred after the first loading dose an additional 10mg/kg of the same drug was given over 10 minutes. If seizures recurred, the patients were loaded with sodium valporate 30 mg/kg diluted in 50 ml normal saline in 15 minutes.