Mass Vaccine and Drug Administration, Bangladesh (MVDA)
Plasmodium Falciparum Malaria
About this trial
This is an interventional prevention trial for Plasmodium Falciparum Malaria focused on measuring Plasmodium Falciparum Malaria, Malaria Vaccine, Malaria Drug Administrations
Eligibility Criteria
Inclusion Criteria: Current residence in a study village irrespective of permanence Age 6 months and above (no upper age limit) Written informed consent provided by participants (or a parent/guardian in case the participant is under 18 years old) Exclusion Criteria: Pregnancy, plan to get pregnant, or breastfeeding. Acute illness requiring intervention A history of an adverse reaction to study drugs/vaccine and prior receipt of any other malaria vaccine or enrolment in another intervention trial.
Sites / Locations
- Alikadam Upazila Health Complex
- Lama Upazila Health Complex
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Active Comparator
Active Comparator
No Intervention
MDA + Vaccine
MDA only
Vaccine only
Control
The participants in MVDA villages will receive R21/Matrix M at M0, M1, M2, and a booster M12 plus DHA/piperaquine and a SLD-PQ at M0, M1, and M2
The participants in MDA only villages will receive DHA/piperaquine and a SLD-PQ at M0, M1, and M2
The participants in vaccine only villages will receive R21/Matrix M at M0, M1, M2, and a booster M12
The participants in control will receive MVDA at the end of the 24th month assuming that MVDA is found to be safe and effective. During M0 to M24, the comparison villages will receive the standard of care as per national malaria treatment guidelines.