ImGTS for Patients With Behavioral and Psychological Symptoms of Dementia (Phase 2)

Inclusion Criteria: Aged 60 years old or older Diagnosed with mild to moderate Alzheimer's dementia according to the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria Montreal Cognitive Assessment-Philippines (MOCA-P) score of 10-20 inclusive Neuropsychiatric Inventory (NPI-12) score 1-50 inclusive Reisberg Scale Stage 4-5 inclusive Stable dose of antidepressants for the past 6 weeks Stable dose of antipsychotics for the past 4 weeks Able to walk unassisted or with minimal assistance, with or without assistive device No other explanation for condition based on reasonable clinical diagnostics Exclusion Criteria: Have mild cognitive impairment (no dementia) Have MOCA-P score less than 10 or more than 20 Other non-amnestic dementia syndromes Have receptive aphasia Have significant visual or hearing impairment Have an active psychiatric disorder prior to Alzheimer dementia diagnosis Had previous episodes of seizures, diagnosis of epilepsy, or intake of antiepileptic or seizure medications Have quadriplegia or paralysis of the dominant hand Have a history of motion sickness Experience claustrophobia Have a diagnosis of a terminal illness or a life expectancy of less than one year