Perinatal Depression & Anxiety (PDA) and Maternal Gut Microbiome
Perinatal Depression, PerinatalAnxiety
About this trial
This is an interventional prevention trial for Perinatal Depression focused on measuring Gut Microbiome, Gut-Brain Axis, Diet, Omega 3 Fatty acids, Probiotics, Fish Oil, Mental Health disorders, Perinatal Depression and anxiety
Eligibility Criteria
Inclusion Criteria Women 18-43 years old 12-35 weeks of gestation Non-smoker/alcohol/recreational drug user Financially stable Clinical diagnosis of lifetime depression/anxiety or PDA but currently well English speaking Exclusion Criteria: BMI≥30 Low income (unable to afford basic daily needs (i.e., shelter, food, etc.) Diagnosis with other major mental health disorders (Bipolar, Psychosis, Addiction, Schizophrenia); Diagnosis with other severe medical conditions (i.e. epilepsy, neurological disorders, etc.) Allergies to fish oils/ingredients in supplements Conditions that require repeated/chronic antibiotic usage Having a child with significant mental/physical disability Single mothers without any kind of family support, Cigarette, alcohol and recreational drug users Women unwilling to switch to study product(s) Multiparous women with young children (i.e. one or more children less than 4 years of age at the time of delivery) Non-English Readers/Speakers
Sites / Locations
- Sunnybrook Health Science Center
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Active Comparator
Gutopia
Gutboost
Gutless
Gutnone
Women in this arm will receive dietary modification, fish oil and probiotics from the time of enrollment till completion of last study visit (12 months postpartum). The dietary modification will be conducted by a dietician that will provide feedback on the participants diet at enrollment, ways to improve diet quality to meet pregnancy needs, and increase prebiotic foods. Weekly follow-ups will be conducted by the research team to ensure dietary target is met and to help address challenges in doing so. The initial dietary consult will be 30-45 minutes long with 10-15 minute for each subsequent follow-up.
Women in this arm will receive a daily probiotic and fish oil supplement from the time of enrollment till 1 year postpartum.
Women in this arm will receive fish oil and placebo probiotic from the time enrollment till 1 year postpartum .
Women in this arm will only be receiving standard care by their obstetrician, and a one time, 30 minutes consult on how to improve baseline diet quality to meet pregnancy needs will be provided by a dietician at the time of enrollment.