Non Inferiority Trial Investigating Surfactants Administered Via MIST (Niftisurf)
Respiratory Distress Syndrome
About this trial
This is an interventional treatment trial for Respiratory Distress Syndrome focused on measuring Pulmonary Surfactant, CPAP, Neonate
Eligibility Criteria
Inclusion Criteria: Preterm infants 28-35 6/7 weeks' gestation and less than 48 hours of age who have a clinical diagnosis of respiratory distress syndrome confirmed by a chest x-ray on nasal continuous positive airway pressure (NCPAP) and FiO2 ≥0.30 Exclusion Criteria: Infants will be excluded if there is a congenital anomaly or an alternative cause for respiratory distress. Infants who require emergent intubation will not be enrolled in the interventions.
Sites / Locations
- Northshore University Healthsystem
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Calfactant (Infasurf)
Poractant alfa (Curosurf)
Neonate, 28-35 weeks gestation, less than 48 hours of age, with respiratory distress syndrome on CPAP > 30% oxygen will be given 3ml/kg of Calfacant
Neonate, 28-35 weeks gestation, less than 48 hours of age, with respiratory distress syndrome on CPAP > 30% oxygen will be given 2.5ml/kg of Poractant alfa.