Effect of Weizmania Coagulans BC99 Intervention on Gut Microbiota and Metabolic Markers in Overweight Adults

Inclusion Criteria: All patients meet the diagnostic criteria for severe illness, and a body mass index (BMI) of ≥ 24kg/m2 is considered overweight; Age 18-65 years old; Without dieting or weight loss, and able to accept dietary intervention, maintain a low-carbon and healthy diet during the trial period; Patients who understand clinical research and commit to complying with research requirements and procedures; Patients who have signed informed consent forms. Able to complete research according to the requirements of the experimental protocol; Exclusion Criteria: Taking items with similar functions to the test subjects in the short term can affect the judgment of the results; Have taken antibiotics 2 weeks before recruitment; Those who stop taking the test sample or add other drugs midway, and cannot determine the efficacy or have incomplete information; Obesity caused by drug treatment (hormones, antidepressants, etc.), endocrine diseases, combined with severe liver and kidney dysfunction, water retention or muscle development; Patients who are pregnant, lactating, stomatal, critically ill, or have potential health conditions that affect metabolism or weight; Neuroendocrine system diseases (hypothyroidism, polycystic ovary syndrome, Cushing's syndrome, hypothalamic injury, etc.); Have a clear history of gastrointestinal diseases (such as ulcers, gastrointestinal bleeding, irritable bowel syndrome, celiac disease, inflammatory bowel disease, Crohn's disease, or other diseases) and a history of surgery (such as weight loss surgery, bandaging surgery, gastrointestinal anastomosis surgery, and intestinal resection surgery); Hereditary obesity Hereditary obesity (such as PWS, Down's syndrome), metabolic obesity (such as obesity reproductive impotence syndrome), endocrine obesity (such as Kirschner's syndrome, hypothyroidism), any disease affecting liver fibrosis or steatosis, metabolic disease (such as hypothyroidism/hyperthyroidism, type 1 or type 2 diabetes, etc.); Patients who changed their diet type during the study period; Patients with severe diseases such as cardiovascular, cerebrovascular, liver, kidney, and hematopoietic systems, as well as endocrine diseases, and mental illnesses; According to the researcher's judgment, the condition of the subject does not qualify them to participate in the study.